Self-healing gels based on constitutional dynamic chemistry and their potential applications

Chemical Society Reviews
Zhao WeiYong Mei Chen


As representative soft materials with widespread applications, gels with various functions have been developed. However, traditional gels are vulnerable to stress-induced formation of cracks. The propagation of these cracks may affect the integrity of network structures of gels, resulting in the loss of functionality and limiting the service life of the gels. To address this challenge, self-healing gels that can restore their functionalities and structures after damage have been developed as "smart" soft materials. In this paper, we present an overview of the current strategies for synthesizing self-healing gels based on the concept of constitutional dynamic chemistry, which involves molecular structures capable of establishing dynamic networks based upon physical interactions or chemical reactions. The characterization methods of self-healing gels and the key factors that affect self-healing properties are analyzed. We also illustrate the emerging applications of self-healing gels, with emphasis on their usage in industry (coatings, sealants) and biomedicine (tissue adhesives, agents for drug or cell delivery). We conclude with a perspective on challenges facing the field, along with prospects for future development.


Nov 17, 2001·Chemical Reviews·K Y Lee, D J Mooney
Mar 2, 2002·Science·Xiangxu ChenFred Wudl
Dec 20, 2002·Angewandte Chemie·Stuart J RowanJ Fraser Stoddart
Mar 13, 2003·Journal of the American Chemical Society·Sanford A AsherDavid N Finegold
Mar 20, 2003·Journal of the American Chemical Society·Harry W GibsonJason W Jones
May 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Williams G Skene, Jean-Marie P Lehn
Jul 17, 2004·Annual Review of Biomedical Engineering·Buddy D Ratner, Stephanie J Bryant
Feb 11, 2005·Biomaterials·Kazunori YasudaYoshihito Osada
Mar 17, 2005·Chemical Communications : Chem Comm·Elena Kolomiets, Jean-Marie Lehn
Sep 21, 2005·Chemical Society Reviews·Neralagatta M Sangeetha, Uday Maitra
Jan 5, 2006·Chemistry : a European Journal·Nicolas GiusepponeJean-Marie Lehn
Mar 30, 2006·Journal of the American Chemical Society·Meenakshi Dowlut, Dennis G Hall
Jan 1, 1927·The Biochemical Journal·D J Lloyd, W B Pleass
Dec 21, 2006·Journal of the American Chemical Society·Mathieu FrenetteJuan C Scaiano
Jan 18, 2007·Accounts of Chemical Research·Clinton R SouthMarcus Weck
May 26, 2007·Science·Melinda C Cushing, Kristi S Anseth
Jul 11, 2007·Chemical Society Reviews·John E Moses, Adam D Moorhouse
Aug 21, 2007·Journal of the American Chemical Society·Masaru YoshidaNobutsugu Minami
Nov 13, 1981·Science·D H Freeman, L S Cheung
Oct 17, 2007·Journal of Oleo Science·Tadahiro OzawaShigeyoshi Miyagishi
Oct 25, 2007·Chemical Communications : Chem Comm·Takashi OnoJean-Marie Lehn
Dec 18, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anda Vintiloiu, Jean-Christophe Leroux
Dec 25, 2007·Free Radical Biology & Medicine·Melissa KempDean P Jones
Jul 9, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nitin S Satarkar, J Zach Hilt
Nov 6, 2008·Chemical Communications : Chem Comm·Zaida Rodriguez-Docampo, Sijbren Otto
Jan 10, 2009·Chemistry : a European Journal·P ReutenauerJ-M Lehn
Jun 30, 2009·Cell Transplantation·Timothy P MartensGordana Vunjak-Novakovic
Apr 2, 2010·ACS Applied Materials & Interfaces·Xiaofan LuoPatrick T Mather
Apr 2, 2010·Chemical Communications : Chem Comm·Minh Khanh Nguyen, Doo Sung Lee
Apr 17, 2010·Nanomedicine·Hikmet GeckilUtkan Demirci
Apr 29, 2010·ACS Applied Materials & Interfaces·Amy M PetersonGiuseppe R Palmese
May 27, 2010·Chemical Society Reviews·Stefano BurattiniWayne Hayes
Jul 28, 2010·Angewandte Chemie·Pritam MukhopadhyaySeiji Shinkai
Sep 22, 2010·Colloids and Surfaces. B, Biointerfaces·Zhi RaoTetsushi Taguchi
Oct 23, 2010·Chemical Communications : Chem Comm·Jonathan W Steed

❮ Previous
Next ❯


Oct 27, 2015·Chemical Reviews·Tomasz JungstJürgen Groll
May 6, 2015·Chemical Society Reviews·Nabarun RoyJean-Marie Lehn
Sep 10, 2015·Soft Matter·Hussain HaiderYong Mei Chen
Jan 22, 2015·Macromolecular Rapid Communications·Mei Xiang WangYong Mei Chen
Dec 23, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Joshua E MealyJason A Burdick
Nov 6, 2015·ACS Applied Materials & Interfaces·Cristina BerdugoRein V Ulijn
Sep 19, 2015·Journal of the American Chemical Society·Joost GroenWilhelm T S Huck
May 7, 2015·Advanced Healthcare Materials·Sen HouPeter X Ma
Dec 23, 2015·Chemistry of Materials : a Publication of the American Chemical Society·Jing ChenPeter X Ma
Sep 15, 2015·Journal of Chemical Theory and Computation·Roberto A RodriguezLiao Y Chen
Jul 24, 2015·Chemical Communications : Chem Comm·So Young AnJung Kwon Oh
Jul 7, 2015·Soft Matter·Soma MukherjeeBrent S Sumerlin
Apr 7, 2015·ACS Applied Materials & Interfaces·Ujjal HaldarPriyadarsi De
May 20, 2015·Journal of the American Chemical Society·Béatrice Quiclet-Sire, Samir Z Zard
Apr 29, 2015·Journal of the American Chemical Society·Gregg A BarcanRobert M Waymouth
Feb 3, 2015·Bioconjugate Chemistry·Inoka K DeshapriyaChalla V Kumar
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Bo WangJi-Heung Kim
Mar 10, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Yang GaoYong Mei Chen
Nov 4, 2016·Advanced Materials·Danielle Lynne Taylor, Marc In Het Panhuis
Oct 19, 2016·Macromolecular Rapid Communications·Lenny VoorhaarRichard Hoogenboom
Nov 2, 2016·Chemical Communications : Chem Comm·Marleen Häring, David Díaz Díaz
Sep 14, 2016·Macromolecular Bioscience·Chongyu ZhuDavid M Haddleton
Sep 3, 2016·ACS Applied Materials & Interfaces·Ruixue ChangJianglei Qin
Sep 20, 2016·Macromolecular Rapid Communications·Mani DibaSander C G Leeuwenburgh
Oct 6, 2016·Expert Opinion on Drug Delivery·Dunyin GuKatharina Ladewig
Oct 25, 2016·Chemistry : a European Journal·Etienne BorréMatteo Mauro
Jan 7, 2017·Environmental Science & Technology·Bezawit A GetachewJae-Hong Kim
Mar 1, 2017·Journal of the American Chemical Society·Xiangyi Zhang, Robert M Waymouth
Feb 22, 2017·Macromolecular Rapid Communications·So Young AnJung Kwon Oh
Mar 28, 2017·The Journal of Organic Chemistry·Tobias UrbaniakKatharina Koschek
May 11, 2017·Macromolecular Rapid Communications·Baolin ZhangYou Yu

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical and Diagnostic Research : JCDR
JayasudhaPrasanna K B
Chemical Society Reviews
Eric A AppelOren A Scherman
Die Quintessenz der Zahntechnik
H Schwickerath
Biotechnology and Bioengineering
Akhilesh K GaharwarAli Khademhosseini
© 2021 Meta ULC. All rights reserved