Self-injurious behavior vs. nonsuicidal self-injury: the CNS stimulant pemoline as a model of self-destructive behavior

Crisis
Christopher M BloomAdam M P Miller

Abstract

Historically, the field of self-injury has distinguished between the behaviors exhibited among individuals with a developmental disability (self-injurious behaviors; SIB) and those present within a normative population (nonsuicidal self-injury; NSSI),which typically result as a response to perceived stress. More recently, however, conclusions about NSSI have been drawn from lines of animal research aimed at examining the neurobiological mechanisms of SIB. Despite some functional similarity between SIB and NSSI, no empirical investigation has provided precedent for the application of SIB-targeted animal research as justification for pharmacological interventions in populations demonstrating NSSI. The present study examined this question directly, by simulating an animal model of SIB in rodents injected with pemoline and systematically manipulating stress conditions in order to monitor rates of self-injury. Sham controls and experimental animals injected with pemoline (200 mg/kg) were assigned to either a low stress (discriminated positive reinforcement) or high stress (discriminated avoidance) group and compared on the dependent measures of self-inflicted injury prevalence and severity. The manipulation of stress conditions did ...Continue Reading

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Citations

May 30, 2015·Pediatric Clinics of North America·Liam Crapper, Carl Ernst
Apr 16, 2014·Physiology & Behavior·Ryan J PostChristopher M Bloom
Jan 19, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M S ZinchukA B Guekht

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Methods Mentioned

BETA
environmental stress
pharmacotherapies
amputation

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