PMID: 6970338Feb 5, 1981Paper

Self-MHC-restricted cytotoxic T-cell response without thymic influence

Nature
I Ando

Abstract

The thymus has a central role in directing the maturation and differentiation of T cells. These processes involve movement of cells. These processes involve movement of cells of haematopoietic origin through the thymus and are supposed to require intimate physical contact between T lymphocytes and cells of the thymic epithelium. Cytotoxic T cells (CTLs) induced by virus-infected or hapten-modified autologous cells exhibit dual specificity: for the products of the self major histocompatibility complex (MHC, H--2 in the mouse) and for the foreign antigen. It has been proposed that 'self' specificity of MHC-restricted CTLs is determined by the MHC-encoded antigens expressed on the surface of thymic epithelial cells. We show here that the differentiation of MHC-restricted CTLs can take place without thymic influence. In these experiments, self-MHC-restricted CTLs differentiate form spleen cells of nu/nu mice which lack thymuses after stimulation with 2,4,6-trinitrophenyl (TNP)-coupled autologous cells in the presence of T-cell growth factor.

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Citations

Jan 1, 1996·Veterinary Immunology and Immunopathology·H YamamotoM Onuma
Jan 1, 1996·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·V I Seledtsov, G V Seledtsova
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P J Fink, M J Bevan
Sep 1, 1982·The Journal of Experimental Medicine·V DuprezS J Burakoff
Jan 1, 1984·The Journal of Experimental Medicine·L LeFrancois, M J Bevan
Jul 1, 1983·Annales d'immunologie·J J OwenR Kingston
Jul 1, 1984·The American Journal of Anatomy·J J Owen, E J Jenkinson
Oct 1, 1981·Scandinavian Journal of Immunology·M Hurme, M Sihvola
Dec 1, 1981·European Journal of Immunology·J L MaryanskiJ C Cerottini
Mar 1, 1983·Immunology Today·T Hunig
Jan 1, 1986·Cancer Immunology, Immunotherapy : CII·H OzawaT Kataoka
Jan 1, 1985·Critical Reviews in Clinical Laboratory Sciences·H Bril, R Benner

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