Self-nanoemulsifying drug delivery system of cefpodoxime proxetil containing tocopherol polyethylene glycol succinate

Drug Development and Industrial Pharmacy
Amrita BajajGhansham Munjapara

Abstract

Lipid based drug delivery systems have gained prominence in last decade for drugs with dissolution rate limited oral bioavailability. To improve the solubility, permeability and oral bioavailability of cefpodoxime proxetil, β-lactam antibiotic. It is BCS Class IV drug having solubility 400 µg/mL and 50% oral bioavailability. Self-nanoemulsifying drug delivery system (SNEDDS) using various surfactant and cosurfactants such as tween 80, tocopheryl polyethylene glycol succinate (TPGS), propylene glycol and Capmul MCM as oil phase were prepared. Ternary phase diagrams were constructed to identify stable microemulsion region. Percent transmittance studies helped to shortlist the surfactant-cosurfactant combination. Tween 80 and TPGS as surfactants and Capmul MCM as oil phase were found to produce stable nanoemulsions. Five formulations of SNEDDS had globule size of 55-60 nm and zeta potential of -4 to -11 mV. Self-emulsification time was between 221 and 370 s, while viscosity was dependent on composition of SNEDDS. Cloud point was above 70°C which indicated the retention of in vivo self-emulsifying properties. Average flux for cefpodoxime proxetil (CP) and SNEDDS was 0.104 and 0.985 µg/cm(2) min. Permeability was 19.72 and 206 for C...Continue Reading

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Citations

Mar 20, 2014·Drug Development and Industrial Pharmacy·Bindu RamasahayamSuresh Bandari
Jul 25, 2013·Drug Development and Industrial Pharmacy·Samridhi VermaMohd Neyaz Ahsan
Mar 17, 2015·International Journal of Pharmaceutics·Rania A H Ishak, Rihab Osman
Feb 11, 2015·Clinical Pharmacokinetics·Kamla Pathak, Smita Raghuvanshi
Oct 27, 2016·The Journal of Pharmacy and Pharmacology·Anand JoshiPhillip M Gerk
Jan 13, 2015·Colloids and Surfaces. B, Biointerfaces·Anuj G AgrawalParaag S Gide
Jan 6, 2019·Nutrients·Ching-Yun HsuJia-You Fang
Jun 17, 2020·Colloids and Surfaces. B, Biointerfaces·Manali PatkiKetan Patel
Dec 10, 2020·International Journal of Nanomedicine·Ze-Liang WuRong Xu
Mar 1, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Delaram BabadiAzadeh Haeri

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