PMID: 6169351Aug 1, 1981Paper

Self-nonself recognition by T and B lymphocytes and their roles in autoimmune phenomena

Arthritis and Rheumatism
W O Weigle

Abstract

Evidence is presented which supports the suggestion that whether a given antigen is vulnerable to an autoimmune attack is dependent upon the specific immune status of B cells and T cells to that antigen which, in turn, is dictated by the concentration of self antigen in their microenvironment. That B cells require much higher concentrations of self antigens than do T cells for the maintenance of tolerance is supported by data presented using an experimental model of acquired tolerance to serum proteins. Depending on the immune status of T cells and B cells to self antigen, the following three models are suggested for the early events leading to autoimmunity: 1) polyclonal activation of competent B cells, 2) direct activation of competent T cells, and 3) bypass of specifically tolerant T cells and activation of competent B cells. The role of a regulatory network involving the suppressor cell circuit in the induction and regulation of autoimmunity is discussed.

References

Jun 26, 1975·Nature·E Ruoslahti, H Wigzell
Sep 1, 1976·The Journal of Experimental Medicine·L Ortiz-Ortiz, W O Weigle
Jan 1, 1973·Advances in Immunology·W O Weigle
Mar 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·J M ChillerW O Weigle
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Nov 1, 1964·The Journal of Experimental Medicine·B CINADERA C WARDLAW

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Citations

Feb 1, 1985·The Journal of Clinical Investigation·W H ReevesH G Kunkel
Dec 11, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Susan L Kirshner
Feb 8, 2011·Seminars in Immunology·Paola Zaccone, Anne Cooke
Aug 26, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Q T LemosZ A Andrade
Apr 1, 1982·Current Problems in Cancer·I Penn
Sep 6, 2007·Endocrine Reviews·S Edwin FinebergAlan S Krasner
Jul 30, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·R W DornerT L Moore

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