Mar 31, 2020

Self-administration of heroin by vapor inhalation in female Wistar rats

BioRxiv : the Preprint Server for Biology
A. GutierrezMichael A Taffe

Abstract

Over the last two decades the United States has experienced a significant increase in the abuse of opioid drugs, resulting in record numbers of opioid-related overdoses and deaths. Starting around 2002, there has been an increase in non-medical use of prescription opioids, followed by increased heroin and then fentanyl use. Inhalation has been a common route of administration for opioid drugs, with a documented history spanning back to Mediterranean antiquity and up through modern use with e-cigarette devices, but preclinical reports with inhalation as the model route of administration remain relatively few. This study was conducted to determine the efficacy of e-cigarette vapor inhalation of heroin in rats. Non-contingent exposure to heroin vapor produced slowed tail-withdrawal in male and female rats, demonstrating anti-nociceptive efficacy. Female Wistar rats trained to self-administer heroin vapor exhibited individual preference differences. The most-preferring half of the distribution administered more vapor reinforcers when the concentration of heroin was reduced in the vapor vehicle and when pre-treated with the opioid receptor antagonist naloxone. The anti-nociceptive effect of heroin self-administered by vapor was iden...Continue Reading

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Mentioned in this Paper

Patterns
Cell Assembly
Entire Nervous System
Neurons
Neuronal Plasticity
Neural Stem Cells
Nervous System Structure
Structure
Nervous system DRUGS
Computed (Procedure)

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