Self-organization of Nucleic Acids in Lipid Constructs

Current Opinion in Colloid & Interface Science
Minjee KangCecília Leal

Abstract

Lipids and nucleic acids (NAs) can hierarchically self-organize into a variety of nanostructures of increasingly complex geometries such as the 1D lamellar, 2D hexagonal, and 3D bicontinuous cubic phases. The diversity and complexity of those lipid-NA assemblies are interesting from a fundamental perspective as well as being relevant to the performance in gene delivery and gene silencing applications. The finding that not only the chemical make of the lipid-NA constructs, but their actual supramolecular organization, affects their gene transfection and silencing efficiencies has inspired physicists, chemists, and engineers to this field of research. At the moment it remains an open question how exactly the different lipid-NA structures interact with cells and organelles in order to output an optimal response. This article reviews our current understanding of the structures of different lipid-NA complexes and the corresponding cellular interaction mechanisms. The recent advances in designing optimal lipid-based NA carriers will be introduced with an emphasis on the structure-function relations.

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Citations

Oct 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Hojun KimCecilia Leal
Jun 22, 2018·Angewandte Chemie·Hanna M G BarrigaMolly M Stevens
Jan 1, 2018·Advanced Functional Materials·Minjee KangCecilia Leal
Jan 17, 2020·Liquid Crystals Reviews·Marilyn Porras-Gomez, Cecilia Leal
Nov 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ricardo GasparBruno F B Silva
Dec 29, 2020·Chemistry and Physics of Lipids·Federica PontiGabriele Candiani
Nov 14, 2017·Chemistry of Materials : a Publication of the American Chemical Society·Minjee KangCecilia Leal
Jan 8, 2021·ACS Applied Materials & Interfaces·Sampa SarkarCharlotte E Conn
Aug 14, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Nathan F BouxseinCyrus R Safinya
Sep 26, 2021·International Journal of Pharmaceutics·Marie CaillaudLiliane Massaad-Massade
Nov 10, 2021·Chemical Reviews·Yoo Kyung Go, Cecilia Leal

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