PMID: 7536709Jan 1, 1995Paper

Self peptides bound by HLA class I molecules are derived from highly conserved regions of a set of evolutionarily conserved proteins

Immunogenetics
A L Hughes, M K Hughes

Abstract

An evolutionary analysis of self peptides reported to be bound by HLA class I molecules showed that these peptides are largely derived from proteins that have been highly conserved in the history of mammals. These proteins also often have universal tissue expression and have a higher than average frequency of highly hydrophilic residues. The peptides themselves are generally still more highly conserved than the source proteins and have a higher frequency of highly hydrophobic residues, evidently often being derived from conserved hydrophobic cores of the source proteins. These results suggest that the mechanism by which peptides are derived for MHC presentation may preferentially select peptides from conserved protein regions. In the case of parasite-derived peptides, such a mechanism would be adaptive in that it would reduce the likelihood of escape mutants.

Citations

Feb 1, 1996·Journal of Molecular Evolution·A L Hughes
Aug 11, 2001·Current Opinion in Immunology·S K Kim, R DeMars
Jun 12, 2003·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·A L Hughes
Jun 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Maria Lucchiari-HartzGabriele Niedermann
Oct 2, 2008·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Pamela MukhopadhyayTapash Chandra Ghosh
Jun 2, 2012·PLoS Computational Biology·Rafal MostowySebastian Bonhoeffer
Feb 7, 2016·Journal of Biomedical Informatics·Davorka R JandrlićMirjana D Pavlović
Oct 27, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Danila ValmoriMaha Ayyoub
Jan 1, 2004·Biological Reviews of the Cambridge Philosophical Society·Kyle SummersHolly Snow
Sep 29, 2011·Molecular Systems Biology·Etienne CaronClaude Perreault
Nov 5, 2003·Molecular Biology and Evolution·Liqing Zhang, Wen-Hsiung Li
Oct 16, 2012·AIDS Research and Human Retroviruses·Sajib ChakrabortyMunsi Sahiuzzaman
Jul 1, 2005·Molecular Biology and Evolution·Jing YangWen-Hsiung Li

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