Mar 6, 1999

Self perception in bacteria: quorum sensing with acylated homoserine lactones

Current Opinion in Microbiology
Clay Fuqua, E Peter Greenberg


A variety of Gram-negative bacteria produce membrane permeant, acylated homoserine lactone (HL) pheromones that act as cell density cues. Synthesis and response to these factors requires proteins homologous to the Luxl acylhomoserine lactone synthase and the LuxR transcription factor from Vibrio fischeri. Recent genetic and biochemical studies have begun to provide a mechanistic understanding of acyl HL dependent gene regulation. Examination of the role of acyl HLs in diverse bacteria positions LuxR-Luxl type systems within an increasingly broad regulatory context and suggests that, in some bacteria, they comprise a global regulatory circuit.

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Mentioned in this Paper

Gene Expression Regulation, Bacterial
Homoserine lactone, (S)-isomer
Gram-Negative Bacteria
Repressor Molecules
Aliivibrio fischeri
Nitric Oxide Synthase
LuxR autoinducer binding proteins
Acyl-Homoserine Lactones

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