Self-perspective leads to increased activation of pain processing brain regions in fibromyalgia

Comprehensive Psychiatry
Benjamin RahmAndreas A Joos

Abstract

Dysfunction of central nervous pain processing is assumed to play a key role in primary fibromyalgia (FM) syndrome. This pilot study examined differences of pain processing associated with adopting different interpersonal perspectives. Eleven FM patients and 11 healthy controls (HC) were scanned with functional magnetic resonance imaging. Participants were trained to take either a self-perspective or another person's perspective when viewing the visual stimuli. Stimuli showed body parts in painful situations of varying intensity (low, medium, and high) and visually similar but neutral situations. Patients with FM showed a higher increase in blood oxygen level dependent (BOLD) response, particularly in the supplementary motor area (SMA). All pain-related regions of interest (anterior insula, somatosensory cortices, anterior cingulate cortex, and SMA) showed stronger modulation of BOLD responses in FM patients in the self-perspective. In contrast to pain processing regions, perspective-related regions (e.g. temporoparietal junction) did not differ between FM and HC. The stronger response of all four pain processing cerebral regions during self-perspective is discussed in the light of disturbed bottom-up processing. Furthermore, t...Continue Reading

References

Jul 24, 2001·European Journal of Pain : EJP·J Hardt, H U Gerbershagen
Jul 13, 2002·Arthritis and Rheumatism·Richard H GracelyDaniel J Clauw
Feb 12, 2004·Arthritis and Rheumatism·Thorsten GieseckeDaniel J Clauw
Oct 6, 2004·Cognitive, Affective & Behavioral Neuroscience·India MorrisonNeil Roberts
Nov 13, 2004·Behavioral and Cognitive Neuroscience Reviews·Jean Decety, Philip L Jackson
May 5, 2006·Psychotherapie, Psychosomatik, medizinische Psychologie·Jochen HardtElmar Brähler
Aug 26, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Eric GuedjOlivier Mundler
Apr 13, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anil KuchinadM Catherine Bushnell
Nov 13, 2007·Journal of Interpersonal Violence·Christine A WalshMichael Boyle
Oct 14, 2008·NeuroImage·Markus BurgmerBettina Pfleiderer
Feb 3, 2009·Neuron·David Borsook, Lino Becerra
Apr 3, 2009·Annals of the New York Academy of Sciences·Tania Singer, Claus Lamm
Apr 28, 2009·Nature Neuroscience·Nikolaus KriegeskorteChris I Baker
Oct 1, 2009·Arthritis and Rheumatism·Richard E HarrisDaniel J Clauw
Jan 9, 2010·The American Journal of Medicine·Daniel J Clauw
Mar 17, 2010·Zeitschrift für Psychosomatische Medizin und Psychotherapie·Ralf NickelUlrich T Egle
Feb 10, 2011·International Journal of Rheumatic Diseases·Gene-Siew NgianGeoffrey O Littlejohn
Sep 14, 2011·Arthritis and Rheumatism·Bradley R FoersterRichard E Harris
Sep 29, 2011·The Journal of Pain : Official Journal of the American Pain Society·Jennifer M GlassTobias Schmidt-Wilcke
Nov 19, 2011·Best Practice & Research. Clinical Rheumatology·Richard H Gracely, Kirsten R Ambrose
Nov 24, 2011·Pain Research and Treatment·Lucie A Low, Petra Schweinhardt
Dec 2, 2011·Human Brain Mapping·Emma G Duerden, Marie-Claire Albanese
Jun 12, 2012·Developmental Cognitive Neuroscience·Jean Decety, Margarita Svetlova
Jul 14, 2012·Annals of the Rheumatic Diseases·Yvonne C LeeVivian P Bykerk
May 21, 2013·The Journal of Pain : Official Journal of the American Pain Society·Rachel F SmallwoodDonald A Robin
Sep 24, 2013·Nursing Research and Practice·Victoria MenziesColleen Jackson-Cook
Nov 19, 2013·Annals of Neurology·Jordi SerraHugh Bostock
Nov 26, 2013·NeuroImage. Clinical·Marta CekoPetra Schweinhardt

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Citations

Jun 27, 2017·PloS One·Sven VannesteDirk De Ridder
Nov 22, 2016·Journal of Neuroscience Research·Arpana GuptaLisa A Kilpatrick

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