Self-powered enzyme micropumps

Nature Chemistry
Samudra SenguptaAyusman Sen

Abstract

Non-mechanical nano- and microscale pumps that function without the aid of an external power source and provide precise control over the flow rate in response to specific signals are needed for the development of new autonomous nano- and microscale systems. Here we show that surface-immobilized enzymes that are independent of adenosine triphosphate function as self-powered micropumps in the presence of their respective substrates. In the four cases studied (catalase, lipase, urease and glucose oxidase), the flow is driven by a gradient in fluid density generated by the enzymatic reaction. The pumping velocity increases with increasing substrate concentration and reaction rate. These rechargeable pumps can be triggered by the presence of specific analytes, which enables the design of enzyme-based devices that act both as sensor and pump. Finally, we show proof-of-concept enzyme-powered devices that autonomously deliver small molecules and proteins in response to specific chemical stimuli, including the release of insulin in response to glucose.

References

Mar 1, 1981·Diabetes Care
Jan 27, 1999·Journal of Pharmacological and Toxicological Methods·A K Dash, G C Cudworth
Jul 25, 2000·Analytical Chemistry·J KhandurinaJ M Ramsey
Jan 11, 2001·Biochimica Et Biophysica Acta·A Svendsen
Feb 28, 2001·Fresenius' Journal of Analytical Chemistry·S C JakewayE L Russell
Jul 30, 2005·Chemistry : a European Journal·Walter F PaxtonThomas E Mallouk
Aug 11, 2005·Physical Review Letters·Ramin GolestanianArmand Ajdari
Dec 8, 2005·Journal of the American Chemical Society·Timothy R KlineAyusman Sen
Nov 16, 2006·Journal of the American Chemical Society·Walter F PaxtonAyusman Sen
Jun 7, 2007·Journal of the American Chemical Society·Michael E IbeleAyusman Sen
Aug 7, 2007·Physical Review Letters·Jonathan R HowseRamin Golestanian
Jun 4, 2008·Physical Review Letters·Ubaldo Córdova-Figueroa, John F Brady
Apr 9, 2009·Journal of the American Chemical Society·Hua YuDavid C Schwartz
May 15, 2009·Scientific American·Thomas E Mallouk, Ayusman Sen
Jul 22, 2009·Chemistry, an Asian Journal·Samuel Sanchez, Martin Pumera
Oct 20, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Tad Hogg, Robert A Freitas
Nov 17, 2009·Small·Tihana MirkovicGeoffrey A Ozin
Jan 30, 2010·Journal of the American Chemical Society·Hari S MuddanaPeter J Butler
Feb 4, 2010·Physical Chemistry Chemical Physics : PCCP·Yiying HongAyusman Sen
Mar 25, 2010·Journal of the American Chemical Society·Oscar R MirandaVincent M Rotello
Apr 15, 2010·The Journal of Physical Chemistry. a·Hua KeKenneth Showalter
Sep 15, 2010·Advanced Materials·In-Kook Jun, Henry Hess
Feb 23, 2011·Chemical Society Reviews·Yongfeng MeiOliver G Schmidt
Apr 7, 2011·Chemical Communications : Chem Comm·Martin Pumera
Apr 21, 2011·Physical Chemistry Chemical Physics : PCCP·Alexander A SolovevOliver G Schmidt
Sep 29, 2011·Angewandte Chemie·Ryan PavlickAyusman Sen
Feb 4, 2012·Angewandte Chemie·Hua ZhangScott T Phillips
May 23, 2012·Chemistry, an Asian Journal·Guanjia Zhao, Martin Pumera
Aug 14, 2012·Angewandte Chemie·Samudra SenguptaAyusman Sen
Sep 14, 2012·Journal of the American Chemical Society·Vinita YadavAyusman Sen
Nov 21, 2012·Nanoscale·Debabrata PatraAyusman Sen
Jan 12, 2013·Journal of the American Chemical Society·Samudra SenguptaAyusman Sen

Citations

Mar 8, 2014·ACS Nano·Samudra SenguptaAyusman Sen
Feb 11, 2016·ACS Nano·Xing MaSamuel Sanchez
Feb 24, 2016·Proceedings of the National Academy of Sciences of the United States of America·Isamar Ortiz-RiveraAnna C Balazs
Feb 1, 2015·Proceedings of the IEEE·Metin SittiEric Diller
Nov 17, 2015·The Journal of Chemical Physics·Peter H Colberg, Raymond Kapral
Jun 23, 2015·Annual Review of Biophysics·Vinita YadavAyusman Sen
May 29, 2015·Cellular and Molecular Bioengineering·Peter J ButlerAyusman Sen
Jun 3, 2016·The Journal of Chemical Physics·Patrick KreisslJoost de Graaf
Jun 25, 2016·Scientific Reports·Meng ShiFeng Xu
Sep 27, 2016·ACS Nano·Xing MaSamuel Sanchez
Jan 28, 2017·Soft Matter·Ran NiuJoost de Graaf
May 12, 2017·Journal of the American Chemical Society·Krishna Kanti Dey, Ayusman Sen
Dec 2, 2014·Chemical Communications : Chem Comm·Wei WangThomas E Mallouk
Mar 28, 2017·Soft Matter·Lyanne ValdezAyusman Sen
Dec 7, 2016·Angewandte Chemie·Weiwei QinChunhai Fan
Jan 27, 2017·Chemical Communications : Chem Comm·Thomas FarrugiaStephen Mann
Dec 28, 2016·Advanced Materials·Tailin XuShutao Wang
Feb 18, 2017·Nature Communications·Sambeeta DasAyusman Sen
Jul 26, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Oleg E ShklyaevAnna C Balazs
Feb 28, 2018·Chemical Communications : Chem Comm·Elizabeth EllisTung-Chun Lee
Apr 4, 2018·Angewandte Chemie·Mingjun XuanSamuel Sanchez
Apr 23, 2016·Lab on a Chip·Chao ZhouWei Wang
Dec 9, 2014·Lab on a Chip·Samuel Sanchez
Dec 17, 2014·Angewandte Chemie·Samuel SanchezJaideep Katuri
Aug 21, 2014·Angewandte Chemie·Sergi Hernàndez-NavarroFrancesc Sagués
Aug 11, 2018·Angewandte Chemie·Mingjun XuanQiang He
Apr 2, 2016·Science Advances·Oleg E ShklyaevAnna C Balazs
Nov 3, 2018·Proceedings of the National Academy of Sciences of the United States of America·Ah-Young JeeTsvi Tlusty
Jul 26, 2018·Angewandte Chemie·Krishna Kanti Dey
Jul 4, 2019·Angewandte Chemie·Hailong CheJan C M van Hest
Jul 10, 2019·Angewandte Chemie·Yuxing JiQiang He
Jan 11, 2020·Advanced Materials·Michael M LerchJoanna Aizenberg
Jun 17, 2014·Nanoscale·Szilveszter Gáspár
May 22, 2018·Frontiers in Chemistry·Apabrita MallickSoumyajit Roy
Nov 18, 2018·Interface Focus·N Amy YewdallJan C M van Hest
Oct 12, 2018·The Journal of Chemical Physics·Pierre Gaspard, Raymond Kapral
Apr 26, 2019·Proceedings of the National Academy of Sciences of the United States of America·Abhrajit LaskarAnna C Balazs
Sep 23, 2014·Advanced Materials·Larisa FloreaDermot Diamond
Jun 28, 2016·Small·David A GregoryStephen J Ebbens
Nov 20, 2019·Nature Nanotechnology·Ambika SomasundarAyusman Sen
Dec 10, 2017·The Journal of Chemical Physics·Pierre Gaspard, Raymond Kapral
Nov 6, 2018·Micromachines·Conghui LiuXueji Zhang
Nov 22, 2019·Nature Communications·Federico LanciaNathalie Katsonis
Aug 14, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Motilal MatheshDaniela A Wilson
Apr 22, 2017·Nature Chemistry·Yingfeng TuDaniela A Wilson
Dec 28, 2018·Science Advances·Abhrajit LaskarAnna C Balazs
Dec 15, 2018·Angewandte Chemie·Benjamin M TansiAyusman Sen
Jul 15, 2020·Chemical Communications : Chem Comm·Rohit VarshneyDebabrata Patra
Jan 21, 2021·Chemical Society Reviews·Jinhua Li, Martin Pumera

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