Self-powered infusion microfluidic pump for ex vivo drug delivery

Biomedical Microdevices
Francesco Dal DossoJeroen Lammertyn

Abstract

In this work, we present a new iSIMPLE concept (infusion Self-powered Imbibing Microfluidic Pump by Liquid Encapsulation), which requires no external power for activation nor liquid manipulation, it is easy to use while its fabrication method is extremely simple, inexpensive and suited for mass replication. The pump consists of a working liquid, which is - after finger activation - absorbed in a porous material (e.g. filter paper). The air expelled from the porous material increases the pressure in the downstream outlet channel and propels the outlet liquid (i.e. the sample) through the channel or ejects it. Here we investigated the influence of different filter papers on the iSIMPLE flow rates, achieving a wide range from 30 down to 0.07 μL/min. We also demonstrated the versatility of the iSIMPLE in terms of the liquid volume that can be manipulated (from 0.5 μL up to 150 μL) and the working pressure reaching 64 kPa, unprecedented high for a self-powered microfluidics pump. In addition, using a 34 G microneedle mounted on the iSIMPLE, we successfully injected liquids with different viscosities (from 0.93 up to 55.88 cP) both into an agarose matrix and a skin-like biological ex vivo substrate (i.e. chicken breast tissue). This ...Continue Reading

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Citations

Aug 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hosub LimJinkee Lee
Jun 9, 2020·Biomicrofluidics·Linfeng XuKwang W Oh
Nov 8, 2018·Biomedical Microdevices·Mohd Anuar Md AliBurhanuddin Yeop Majlis
May 15, 2021·Scientific Reports·Aryan Mehboudi, Junghoon Yeom

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