Self-protection against aminoglycoside ototoxicity in guinea pigs

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
J A A de OliveiraM H de Andrade

Abstract

Amikacin is a semisynthetic aminoglycoside. It acts against most of the microbial species. Amikacin limitation of the therapeutic application is the ototoxicity which promotes permanent lesions in the cochlear system. Aminoglycoside antibiotics have ototoxic potential. The target cells are preferentially the outer hair cells in the cochlear basal turns. Amynoglicoside antibiotics can quelate iron forming a complex with oxidate properties and promotes the formation of free radicals. Responsible for production of lesions in the hair cells. The objective of the present investigation was to determine whether the use of the aminoglycoside amikacin at small doses may lead to the occurrence of some types of resistance to or protection against ototoxicity of the drug by analyzing lesions to the organ of Corti by scanning electron microscopy. The study was conducted on 31 guinea pigs that were divided into 4 groups, amikacin was administered intramuscularly. The groups consisted of: group A = control group: 5 animals (10 cochleae); group B = 5 animals (10 cochleae), amikacin 20 mg/kg/day for 30 days; group C = 7 animals (13 cochleae), amikacin 400 mg/kg/day for 12 days; group d = 14 animals (26 cochleae) amikacin 20 mg/kg/day for 30 day...Continue Reading

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Citations

Jan 23, 2010·Journal of the Association for Research in Otolaryngology : JARO·Elizabeth A FernandezWilliam W Clark
Nov 29, 2011·International Journal of Otolaryngology·M E HuthA G Cheng
Dec 29, 2007·Drug and Chemical Toxicology·Eloisa Nogueira MaudonnetMiguel Angelo Hyppolito
Dec 8, 2015·Hearing Research·Christopher SpankovichColleen G Le Prell
Oct 11, 2005·Drug Discovery Today·Leonard P Rybak, Craig A Whitworth
Mar 9, 2012·The Annals of Otology, Rhinology, and Laryngology·Lokman UzunHarun Akinci
Nov 2, 2014·The Annals of Otology, Rhinology, and Laryngology·Fadlullah AksoyBurak Ozturk
Jul 25, 2009·Pró-fono : revista de atualização científica·Carla Luiza BaggioMiguel Angelo Hyppolito
Dec 2, 2015·Clinical and Experimental Otorhinolaryngology·Fadlullah AksoyAlev Pektas
Mar 6, 2021·Brazilian Journal of Otorhinolaryngology·Vagner Antonio Rodrigues da SilvaAgricio Nubiato Crespo
May 21, 2021·Antioxidants & Redox Signaling·Ryan T HarrisonEdward Lobarinas
Apr 22, 2020·Audiology & Neuro-otology·Vagner Antonio Rodrigues SilvaAgrício Nubiato Crespo

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