PMID: 43553Jan 1, 1979

Self-rated sedation and plasma concentrations of desmethyldiazepam following single doses of clorazepate

Psychopharmacology
D J GreenblattA Georgotas

Abstract

Plasma concentrations of desmethyldiazepam (DMDZ) and intensity of self-rated sedation (SRS) were measured at multiple points in time during 6 h after a single 15 mg oral dose of clorazepate dipotassium. Mean plasma DMDZ levels and mean SRS scores both became maximal at 1.0--2.5 h after drug dosage. By 6 h, however, mean SRS had returned to the predrug baseline score while mean DMDZ concentration fell only slighty from the maximum value. Disappearance of SRS despite persistence of high DMDZ levels might be due to adaptation or tolerance. If this is the case, subjective effects of benzodiazepines may depend upon duration of drug exposure as well as dose and concentration.

References

Sep 1, 1978·Clinical Pharmacology and Therapeutics·R I ShaderM D Allen
Oct 20, 1978·JAMA : the Journal of the American Medical Association·D J GreenblattR I Shader
Jul 1, 1978·British Journal of Clinical Pharmacology·C Maxwell
Jul 1, 1978·Acta Pharmacologica Et Toxicologica·R GrundströmT Hansen
May 1, 1977·The American Journal of Psychiatry·D J GreenblattJ Koch-Weser
Jan 1, 1977·European Journal of Clinical Pharmacology·S M MacLeodE M Sellers
Jun 1, 1966·Japanese Journal of Pharmacology·K Matsuki, T Iwamoto

Citations

Jan 1, 1985·Psychopharmacology·D N Stephens, H H Schneider
Jan 1, 1984·Progress in Neuro-psychopharmacology & Biological Psychiatry·S E File
Jun 21, 1984·The New England Journal of Medicine·D J GreenblattR I Shader
Mar 1, 1981·The Australian and New Zealand Journal of Psychiatry·M Lader
Oct 1, 1980·Psychosomatics·D J Greenblatt
Jun 1, 1985·British Journal of Clinical Pharmacology·D D BreimerB M Stone
Feb 1, 1986·British Journal of Clinical Pharmacology·J M ScavoneR I Shader
Oct 27, 2005·International Journal of Geriatric Psychiatry·John KennedyRobert W Baker
Mar 1, 1990·Arquivos de neuro-psiquiatria·M A BernikC N Soares
Jan 1, 1988·Psychological Medicine. Monograph Supplement·A HiggittM H Lader
Jan 1, 1981·British Journal of Addiction·H Petursson, M H Lader

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