Self-reactive T cells. IV. Self-reactive T cells induce polyclonal differentiation of IgM-producing B cells in vivo and in vitro

Immunobiology
J Reimann, T Diamantstein

Abstract

Intravenous injection of lymphoblasts (generated in vitro by different T- or B-specific mitogens) induced a polyclonal activation of IgM-producing B cells in vivo in the spleens of syngeneic recipient mice. This polyclonal differentiation of host-derived B cells to IgM-producing plaque-forming cells was stimulated by host-derived self-reactive T cells activated in the splenic lymphoid cell population in response to the syngeneic lymphoblast graft. We found a stable factor in the supernatants of cultures of proliferating self-reactive T cells that induced (antigen-independent) polyclonal maturation, but not proliferation of IgM-producing B cells.

References

Jan 1, 1979·Immunological Reviews·R E BallieuxB J Zegers
Jun 1, 1977·The Journal of Experimental Medicine·R S GehaE Schneeberger
Dec 1, 1978·The Journal of Experimental Medicine·S M FuS R Harris
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Jan 1, 1969·Transplantation Reviews·J F Miller, G F Mitchell
Jun 1, 1969·Journal of Cellular Physiology·R G Miller, R A Phillips
Aug 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·H N ClamanR F Triplett

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