PMID: 6166716May 1, 1981Paper

Self recognition in allogeneic radiation bone marrow chimeras. A radiation-resistant host element dictates the self specificity and immune response gene phenotype of T-helper cells

The Journal of Experimental Medicine
A SingerR J Hodes

Abstract

The specificity of the self-recognition repertoire in fully allogeneic (A {arrow} B), semiallogeneic (A {arrow} A x B and A x B {arrow} A), and double donor (A + B {arrow} A) radiation bone marrow chimeras was assessed by the ability of their spleen cells to generate in vitro primary plaque-forming cell (PFC) responses to trinitrophenyl- keyhole limpet hemocyanin. In contrast to spleen cells from semiallogeneic and double donor chimeras, intact spleen cells from fully allogeneic BI0 {arrow} B10.A and B10.A {arrow} B10 chimeras were not capable of generating responses to trinitrophenyl (TNP)-keyhole limpet hemocyanin. However, cultures containing a mixture of both B10 {arrow} B10.A and B10.A {arrow} B10 spleen cells did respond, demonstrating that all the cell populations required for the in vitro generation of T-dependent PFC responses were able to differentiate into functional competence in a fully allogeneic major histocompatibility complex (MHC) environment. The self recognition repertoire of T-helper cells from fully allogeneic A {arrow} B chimeras was determined to be specific for the recognition of host, not donor, MHC determinants in that they were able to collaborate with cells expressing only host MHC determinants but ...Continue Reading

References

Oct 1, 1975·The Journal of Experimental Medicine·H von BoehmerJ Sprent
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D W Thomas, E M Shevach
Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Jan 1, 1980·The Journal of Experimental Medicine·K OnoéR A Good

❮ Previous
Next ❯

Citations

Jan 1, 1997·Immunologic Research·B Nikolic, M Sykes
Jan 1, 1988·Immunology Today·M Sykes, D H Sachs
Jun 1, 1990·Human Immunology·D H Sachs, F H Bach
Jan 5, 1999·American Journal of Surgery·R D FosterM Niepp
Jul 8, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·N KawaharadaS M Pham
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R E Gress, R J Hodes
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S K Durum, R K Gershon
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D L LongoL A Matis
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M NoguchiK Morikawa
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S W CaughmanA Singer
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K IwabuchiK Onoé
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·E IshiiR A Good
Nov 1, 1981·The Journal of Experimental Medicine·L H GlimcherR H Schwartz
Feb 1, 1982·The Journal of Experimental Medicine·N A Speck, S K Pierce
Nov 1, 1983·The Journal of Experimental Medicine·E S Groves, A Singer
Dec 1, 1988·The Journal of Experimental Medicine·M G RoncaroloH Spits
May 23, 1998·The Journal of Experimental Medicine·Y G YangM Sykes
Mar 7, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Simon JanesKathryn Wood
Dec 28, 1999·Transplantation·A M BartholomewA B Cosimi
Nov 14, 2007·Transplantation·Yuuki HayashiTadatoshi Takayama

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.