Self-referenced photonic molecule bio(chemical)sensor

Optics Letters
Svetlana V Boriskina, Luca Dal Negro

Abstract

We report a new type of optical biosensor capable of differentiating between bulk and surface perturbations of the ambient refractive index as well as between specific and nonspecific binding of molecules on the sensor surface. The proposed detection scheme is based on tracking the shifts of hybridized bonding and antibonding optical modes in coupled optical microcavities (photonic molecules). We demonstrate that by using two measurements of spectral shifts it is possible to discriminate between surface and volume index perturbation, to detect specific target molecules in a complex environment and to estimate the thickness of thin layers of adsorbed molecules.

References

Aug 29, 2003·Biophysical Journal·Frank VollmerAlbert Libchaber
May 27, 2006·Optics Letters·Andrea M Armani, Kerry J Vahala
Jul 1, 2008·Nature Methods·Frank Vollmer, Stephen Arnold
May 23, 2009·Annals of Biomedical Engineering·Hope T BeierKenith E Meissner

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Citations

Jun 21, 2016·Sensors·Giancarlo C Righini, Silvia Soria
Feb 22, 2012·Sensors·Silvia SoriaGiancarlo C Righini
Jan 4, 2012·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Martin Baaske, Frank Vollmer
Feb 12, 2014·Applied Optics·Kai-Jun CheYong-Zhen Huang
Mar 14, 2013·Optics Express·Kai-Jun CheZhi-Ping Cai
Mar 15, 2016·Advances in Optics and Photonics·Matthew R ForemanFrank Vollmer
Feb 6, 2013·Optics Letters·Bo PengLan Yang

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