Self-referential processing and the prefrontal cortex over the course of depression: a pilot study

Journal of Affective Disorders
Cédric LemognePhilippe Fossati

Abstract

Depressed patients exhibit cognitive biases, including maladaptive self-focus. In a previous functional magnetic resonance imaging (fMRI) study, the dorsal medial prefrontal cortex (MPFC) activation during self-referential versus semantic processing was unique to patients, as was the left dorsolateral prefrontal cortex (DLPFC) activation. The aim of this pilot study was to examine whether this pattern was stable over the course of depression. Sixteen participants (8 depressed inpatients, 8 healthy controls) viewed personality traits during fMRI and judged whether each trait described them or not ('self' condition), or whether it described a socially desirable trait or not ('general' condition). There were 2 scanning sessions with an interval of at least 6weeks, in which patients received an antidepressant treatment. After a mean duration of 9 weeks, depressed patients displayed a more balanced activation of the left DLPFC but a greater activation of the dorsal MPFC in 'self' versus 'general' condition remained. The small sample size and heterogeneous clinical features prevented subgroups analyses between responders and non-responders. The change of the left DLPFC activation suggests that antidepressants are associated with a mo...Continue Reading

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Citations

Jun 4, 2010·Social Cognitive and Affective Neuroscience·Cédric LemognePhilippe Fossati
Feb 22, 2014·European Archives of Psychiatry and Clinical Neuroscience·Heidelore BackesAxel Krug
Dec 3, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Nir LipsmanGeorg Northoff
Mar 5, 2016·Developmental Cognitive Neuroscience·Kailyn A L BradleyVilma Gabbay
Jan 1, 2013·Biological Psychiatry·Baojuan LiDewen Hu
Dec 15, 2015·Psychiatry Research. Neuroimaging·Pauline DelaveauPhilippe Fossati
Apr 27, 2010·Psychiatry Research·Scott C MatthewsMartin P Paulus
Jul 2, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Alexander KhalafHoward Aizenstein
Jun 15, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·William R MarchandNicole Wood
Jan 21, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Simone GrimmGeorg Northoff
Dec 28, 2010·Journal of Affective Disorders·Cédric LemognePhilippe Fossati
Oct 30, 2010·Journal of Affective Disorders·Pauline DelaveauPhilippe Fossati
Aug 3, 2012·Journal of Affective Disorders·Paloma Fernández-CorcueraEdith Pomarol-Clotet
Jan 28, 2014·Journal of Psychiatric Research·Doreen M OlvetRamin V Parsey
Jul 4, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J Nienke PannekoekNic J A van der Wee
Jun 16, 2016·Psychophysiology·Randy P AuerbachDiego A Pizzagalli
Mar 31, 2017·Journal of Geriatric Psychiatry and Neurology·Filippo CieriMassimo di Giannantonio
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Apr 29, 2018·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Xilong CuiWenbin Guo
Jul 19, 2018·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Sabrina GoldeDiana Raufelder
Apr 8, 2020·The International Journal of Neuroscience·Kelly A DuranJulian Paul Keenan
Jul 6, 2014·Psychosomatic Medicine·Ricardo CácedaCharles B Nemeroff
Jan 26, 2020·Cognitive, Affective & Behavioral Neuroscience·Sucharit KatyalPhilippe Goldin
Dec 12, 2017·Psychiatry Journal·Christopher W T Miller
Oct 2, 2020·Scientific Reports·Shaoming WangDavid V Smith

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