Self-regulated mechanism of Plk1 localization to kinetochores: lessons from the Plk1-PBIP1 interaction.

Cell Division
K S LeeJung-Eun Park

Abstract

Mammalian polo-like kinase 1 (Plk1) has been studied extensively as a critical element in regulating various mitotic events during M-phase progression. Plk1 function is spatially regulated through the targeting activity of the conserved polo-box domain (PBD) present in the C-terminal non-catalytic region. Recent progress in our understanding of Plk1 localization to the centromeres shows that Plk1 self-regulates its initial recruitment by phosphorylating a centromeric component PBIP1 and generating its own PBD-binding site. Paradoxically, Plk1 also induces PBIP1 delocalization and degradation from the mitotic kinetochores late in the cell cycle, consequently permitting itself to bind to other kinetochore components. Thus, PBIP1-dependent self-recruitment of Plk1 to the interphase centromeres serves as a prelude to the efficient delivery of Plk1 itself to other kinetochore components whose interactions with Plk1 are vital for proper mitotic progression.

References

Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·K S LeeR L Erikson
Mar 16, 2004·The Journal of Biological Chemistry·Junjun LiuJames L Maller
Jun 3, 2004·Nature Reviews. Molecular Cell Biology·Francis A BarrErich A Nigg
Jan 11, 2005·Oncogene·Drew M LoweryMichael B Yaffe
Apr 20, 2005·Oncogene·Marcel A T M van Vugt, René H Medema
Nov 17, 2005·Molecular and Cellular Biology·Yukinori MinoshimaTatsuo Fukagawa
Dec 27, 2005·Nature Cell Biology·Hidemasa GotoMasaki Inagaki
Mar 25, 2006·Nature Reviews. Cancer·Klaus Strebhardt, Axel Ullrich
Apr 20, 2006·Nature Cell Biology·Daniel R FoltzDon W Cleveland
Apr 22, 2006·Cell Cycle·Barbara C M van de Weerdt, René H Medema
Feb 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Begoña García-AlvarezGuillermo Montoya

❮ Previous
Next ❯

Citations

Aug 24, 2013·Nature Reviews. Molecular Cell Biology·H Christian Reinhardt, Michael B Yaffe
Nov 6, 2009·Annual Review of Genetics·Marcin R Przewloka, David M Glover
Oct 5, 2013·BMC Bioinformatics·Henrik FailmezgerAchim Tresch
Sep 2, 2015·The Journal of Cell Biology·Xiaolong ZhuoChuanmao Zhang
Mar 17, 2011·The Biochemical Journal·Hoi Tang Ma, Randy Y C Poon
May 15, 2008·Developmental Cell·Mark PetronczkiJan-Michael Peters
Nov 11, 2018·Cytoskeleton·Erica G Colicino, Heidi Hehnly
Mar 27, 2019·International Journal of Experimental Pathology·Yuhua FengMeizuo Zhong
Jul 26, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michel D WissingSushant K Kachhap
Sep 5, 2020·Journal of Drug Targeting·Ilma ShakeelMd Imtaiyaz Hassan
Nov 30, 2018·Journal of Veterinary Science·Jeonghyeon Moon, Sangho Roh
Apr 2, 2011·The Journal of Biological Chemistry·Young H KangKyung S Lee
Apr 1, 2014·Molecular & Cellular Oncology·Stephane Schmucker, Izabela Sumara
Jun 1, 2021·Frontiers in Cell and Developmental Biology·Xiangmei ZhangXian-Jie Yang

❮ Previous
Next ❯

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.