Self-regulation therapy increases frontal gray matter in children with fetal alcohol spectrum disorder: evaluation by voxel-based morphometry

Frontiers in Human Neuroscience
Debra W SohJoanne Rovet

Abstract

Children with fetal alcohol spectrum disorder show executive function (EF) deficits, particularly in self-regulation skills, and abnormalities in brain regions critical for these skills. None of the validated EF interventions for these children has been evaluated with regards to impacts on brain structure. Twenty-nine children with FASD were assigned to either an immediate-treatment (TX) or delayed-treatment control (DTC) group (DTC). Nineteen typically developing children served as healthy controls (CT). All received a structural MRI scan and baseline neuropsychological testing, following which the TX group underwent 12 weekly 1.5-h sessions of the Alert Program for Self-Regulation(®). After treatment or a period of ~14 weeks, all received a repeat scan and post-intervention testing. Whole-brain and region-of-interest analyses using voxel-based morphometry evaluated group differences and changes over time in gray matter (GM). Exploratory analyses revealed significant group changes: (1) At baseline, combined TX and DTC groups demonstrated global GM reductions compared with the CT group. (2) Region-of-interest analysis using a frontal mask, comparing post-intervention to pre-intervention results, showed significantly increased G...Continue Reading

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Citations

Jan 23, 2016·Frontiers in Integrative Neuroscience·Clare J Wilhelm, Marina Guizzetti
Nov 19, 2015·Alcoholism, Clinical and Experimental Research·Natasha ReidFrances O'Callaghan
Jul 5, 2016·Alcoholism, Clinical and Experimental Research·Keshav K GuptaTomohiro Shirasaka
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Apr 20, 2018·Alcoholism, Clinical and Experimental Research·Natasha Reid, Christie L M Petrenko
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Jun 28, 2019·International Journal of Environmental Research and Public Health·Babatope O AdebiyiCharlene Erasmus
Feb 5, 2021·Frontiers in Human Neuroscience·Olga Tymofiyeva, Robert Gaschler
Jun 1, 2021·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Lisa K OrdenewitzMirjam N Landgraf

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

MATLAB
VBM
VBM Toolbox
Motherisk
SPM5
CONSORT
Statistical
SPSS
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