Self-reported goiter is associated with a significantly increased risk of gastric noncardia adenocarcinoma in a large population-based Chinese cohort

International Journal of Cancer. Journal International Du Cancer
C C AbnetS M Dawsey

Abstract

Iodine is concentrated by the gastric mucosa, where it may act as an antioxidant. Therefore, iodine deficiency, and its sequelae goiter, may be associated with an increased risk of gastric cancer. We examined the association between self-reported goiter and upper gastrointestinal cancer in a Chinese cohort of 29,584 adults. Using multivariate adjusted Cox models, we found goiter associated with a significantly increased risk of gastric noncardia adenocarcinoma, HR (95% CI) 2.04 (1.01, 4.11) and nonsignificantly with gastric cardia adenocarcinoma, HR (95% CI) 1.45 (0.91, 2.30). We also found a borderline, insignificant increased risk of esophageal squamous cell carcinoma, HR (95% CI) 1.37 (0.97, 1.94). Our findings are consistent with the hypothesis that iodine deficiency is associated with an increased risk of gastric cancer.

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Citations

May 15, 2007·European Journal of Nutrition·Filip GołkowskiBohdan Huszno
Dec 29, 2012·Cancer Causes & Control : CCC·Donald E Henson, Jorge Albores-Saavedra
Aug 9, 2013·International Journal of Molecular Sciences·Adam R BrownFrank A Simmen
Nov 30, 2006·International Journal of Cancer. Journal International Du Cancer·Marta RossiCarlo La Vecchia
Nov 26, 2010·International Journal of Cancer. Journal International Du Cancer·Shih-Wen LinChristian C Abnet
Jul 12, 2013·Journal of Gastric Cancer·Mohammad TabaeizadehBagher Larijani
Oct 20, 2009·Nutrition and Health·Sebastiano Venturi, Mattia Venturi
Jan 18, 2020·Journal of Clinical Medicine·Maria Pina DoreGiovanni Mario Pes

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