Self-Reported Omega-3 Supplement Use Moderates the Association between Age and Exercising Cerebral Blood Flow Velocity in Older Adults

Nutrients
Carolyn S KaufmanSandra A Billinger

Abstract

Cerebral blood flow (CBF) decreases across the lifespan, and chronic conditions such as dementia and stroke accelerate this decline. Impaired CBF results in reduced delivery of oxygen and nutrients, which can damage the brain over time. Thus, there is a need to identify lifestyle interventions, including diet and exercise, to maintain CBF with aging and in the presence of chronic disease. In the present study, we used transcranial Doppler ultrasound to record middle cerebral artery velocity (MCAv), a surrogate measure of CBF, during moderate-intensity exercise in sedentary, cognitively normal older adults (n = 90). A multiple linear regression model (F(4, 85) = 3.21, p = 0.02) showed that self-reported omega-3 supplement use significantly moderated the association between age and mean exercising MCAv in these individuals (p = 0.01). Older age was associated with lower exercising MCAv in the group not taking omega-3 supplements, while exercising MCAv showed no decline with increasing age in the group who reported omega-3 supplement use. These findings suggest omega-3 supplementation may have an important role in the preservation of CBF with aging.

References

Feb 1, 1990·Brain : a Journal of Neurology·K L LeendersS Herold
Jul 8, 2000·Stroke; a Journal of Cerebral Circulation·J M SerradorR L Bondar
Apr 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Diego LópezM Teresa Mitjavila
Jan 24, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Andrei V AlexandrovUNKNOWN American Society of Neuroimaging Practice Guidelines Committee
Sep 25, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Garabed Eknoyan
Oct 28, 2010·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Andrei V AlexandrovUNKNOWN American Society of Neuroimaging Practice Guidelines Committee
Nov 12, 2010·Nature·David AttwellEric A Newman
Oct 19, 2011·The British Journal of Nutrition·Matthew P PaseJerome Sarris
Oct 31, 2012·Vascular Health and Risk Management·Alex E RoherThomas G Beach
Mar 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Toshinori HoshiShangwei Hou
Nov 2, 2013·NeuroImage. Clinical·Ze WangUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 16, 2014·Food & Function·Marcela A MartinsAntônio Cláudio Mendes-Ribeiro
Mar 25, 2016·The Journal of Physiology·Ryan L Hoiland, Philip N Ainslie
Jul 28, 2016·Neurobiology of Aging·Harm J van de HaarWalter H Backes
Oct 4, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G ColussiL A Sechi
Nov 1, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Chang-Yang XingRong Zhang
Jan 29, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Patrice BrassardPhilip N Ainslie
Jun 8, 2017·Circulation·Frank J WoltersUNKNOWN Heart-Brain Connection Collaborative Research Group
Sep 9, 2017·Stroke; a Journal of Cerebral Circulation·Philip B GorelickUNKNOWN American Heart Association/American Stroke Association
Sep 16, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jason-Flor V SisanteSandra A Billinger
Jun 20, 2019·Nutrición hospitalaria·Amelia Marti Del Moral, Francesca Fortique
Jul 1, 2019·Journal of Alzheimer's Disease : JAD·Yumei LiuSandra A Billinger
Aug 27, 2019·Journal of Neurologic Physical Therapy : JNPT·Katie S KempfSandra A Billinger
Nov 7, 2019·Lipids in Health and Disease·Rebecca L CookHelen T O'Connor
Nov 22, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Mohammed R AlwatbanSandra A Billinger
Oct 27, 2020·Cardiopulmonary Physical Therapy Journal·Sophy J PerdomoSandra A Billinger

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Citations

Mar 12, 2021·Journal of Applied Physiology·Mohammed R AlwatbanSandra A Billinger
Mar 19, 2021·Alzheimer Disease and Associated Disorders·Carolyn S KaufmanSandra A Billinger

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Software Mentioned

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