Self-Reported Physical Activity is Associated with Tau Burden Measured by Positron Emission Tomography

Journal of Alzheimer's Disease : JAD
Belinda M BrownVictor L Villemagne

Abstract

Numerous animal studies have reported exercise reduces the accumulation of Alzheimer's disease pathology, including amyloid-β (Aβ) and tau. Furthermore, we previously reported a relationship between higher levels of physical activity (PA) and lower brain Aβ burden in a human population. The recent advent of tau positron emission tomography (PET) tracers enables us to extend our investigations into the evaluation of the relationship between PA and brain tau burden. Utilizing data from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, we have examined the cross-sectional relationship between habitual PA and PET-quantified tau burden. Forty-three cognitively healthy older adults were categorized into low-moderate PA (LMPA; n = 16) or high PA (HPA; n = 27), based on self-reported PA levels. Tau PET imaging with the AV1451 tracer was conducted on all participants. The LMPA group had significantly higher neocortical tau burden (presented as a z-score; 1.22±1.98), compared to the HPA group (z-score: - 0.28±1.18). The difference between the LMPA and HPA groups was also evident when examining regional tau burden in the temporoparietal cortex and the prefrontal cortex. Our results suggest an association between self-reported...Continue Reading

References

May 1, 1995·Neurobiology of Aging·H Braak, E Braak
Feb 5, 1999·Progress in Brain Research·H BraakE Braak
Mar 20, 2001·Archives of Neurology·D LaurinK Rockwood
Aug 6, 2003·Medicine and Science in Sports and Exercise·Cora L CraigPekka Oja
Sep 24, 2004·JAMA : the Journal of the American Medical Association·Jennifer WeuveFrancine Grodstein
Apr 29, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul A AdlardCarl W Cotman
Oct 12, 2007·Brain : a Journal of Neurology·Kerryn E PikeChristopher C Rowe
Sep 5, 2008·JAMA : the Journal of the American Medical Association·Nicola T LautenschlagerOsvaldo P Almeida
Jul 1, 2007·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Ron BrookmeyerH Michael Arrighi
Sep 8, 2010·Annals of Neurology·Kelvin Y LiangDenise Head
Jan 11, 2012·Archives of Neurology·Denise HeadJohn C Morris
Nov 22, 2012·Translational Psychiatry·B M BrownUNKNOWN AIBL research group
Sep 5, 2014·Neurology·Belinda M BrownUNKNOWN AIBL Research Group
Oct 29, 2014·Acta Neuropathologica·John F CraryPeter T Nelson
Nov 30, 2014·Molecular Neurodegeneration·Odochi Ohia-NwokoJason L Eriksen
Mar 5, 2016·Neuron·Michael SchöllWilliam J Jagust
Jun 12, 2016·Brain : a Journal of Neurology·Brian A GordonTammie L S Benzinger
Jul 17, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·David A MerrillGary W Small

❮ Previous
Next ❯

Citations

Jan 16, 2019·Annual Review of Public Health·Bryan D James, David A Bennett
May 13, 2020·Journal of Neurochemistry·Guilherme B de FreitasFernanda G De Felice
Apr 26, 2020·Alzheimer's Research & Therapy·Jaisalmer de Frutos-LucasFernando Maestú
Jan 8, 2021·Chinese Medicine·Abdullahi AlausaAminat Ismail
May 4, 2021·Journal of Alzheimer's Disease : JAD·Taylor J KrivanekKirk R Daffner
Jun 1, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Claire E SextonMaria C Carrillo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.