Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes

Clinical Epigenetics
Lu GaoCarrie V Breton

Abstract

Epigenetic modifications, including DNA methylation, act as one potential mechanism underlying the detrimental effects associated with prenatal tobacco smoke (PTS) exposure. Methylation in a gene called AXL was previously reported to differ in response to PTS. We investigated the association between PTS and epigenetic changes in AXL and how this was related to childhood asthma phenotypes. We tested the association between PTS and DNA methylation at multiple CpG loci of AXL at birth using Pyrosequencing in two separate study populations, the Children's Health Study (CHS, n = 799) and the Newborn Epigenetic Study (NEST, n = 592). Plasma cotinine concentration was used to validate findings with self-reported smoking status. The inter-relationships among AXL mRNA and miR-199a1 expression, PTS, and AXL methylation were examined. Lastly, we evaluated the joint effects of AXL methylation and PTS on the risk of asthma and related symptoms at age 10 years old. PTS was associated with higher methylation level in the AXL gene body in both CHS and NEST subjects. In the pooled analysis, exposed subjects had a 0.51% higher methylation level in this region compared to unexposed subjects (95% CI 0.29, 0.74; p < 0.0001). PTS was also associated...Continue Reading

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Citations

Nov 26, 2019·Experimental Lung Research·Kary Y F TsaiPaul R Reynolds
Nov 7, 2019·Current Opinion in Pulmonary Medicine·Silvia Sánchez-GarcíaJavier Domínguez-Ortega
Feb 20, 2020·Current Opinion in Allergy and Clinical Immunology·Ioana AgacheLiliana Rogozea
Nov 1, 2020·Allergy·Julie WeidnerMadeleine Rådinger
Mar 31, 2021·Clinical Epigenetics·Mojgan SheikhpourVahid Amiri

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Methods Mentioned

BETA
PCR

Software Mentioned

Pyrosequencing
NEST
R
QCpG
SAS ( Statistical Analysis System )
Origene

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