Self-Resistance of Natural Product Producers: Past, Present, and Future Focusing on Self-Resistant Protein Variants

ACS Chemical Biology
Khaled H AlmabrukBenjamin Philmus

Abstract

Nature is a prolific producers of bioactive natural products with an array of biological activities and impact on human and animal health. But with great power comes great responsibility, and the organisms that produce a bioactive compound must be resistant to its biological effects to survive during production/accumulation. Microorganisms, particularly bacteria, have developed different strategies to prevent self-toxicity. Here, we review a few of the major mechanisms including the mechanism of resistance with a focus on self-resistant protein variants, target proteins that contain amino acid substitutions to reduce the binding of the bioactive natural product, and therefore its inhibitory effects are highlighted in depth. We also try to identify some future avenues of research and challenges that need to be addressed.

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Citations

Feb 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jack G Ganley, Emily R Derbyshire
Oct 7, 2020·Natural Product Reports·Roberto G S BerlinckIgor D Jurberg
Jan 6, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jason StahleckerMehmet Direnç Mungan
Jul 10, 2019·Journal of Molecular Biology·Timothy A Wencewicz
Mar 13, 2021·Natural Product Reports·Xingwang ZhangShengying Li
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Nov 10, 2020·ACS Infectious Diseases·Venkateswarlu YarlagaddaGerard D Wright
Nov 5, 2021·Journal of Agricultural and Food Chemistry·Jiayu LiuFengquan Liu

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