Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating.

ELife
Rupamanjari MajumderDaniël A Pijnappels

Abstract

Homeostatic regulation protects organisms against hazardous physiological changes. However, such regulation is limited in certain organs and associated biological processes. For example, the heart fails to self-restore its normal electrical activity once disturbed, as with sustained arrhythmias. Here we present proof-of-concept of a biological self-restoring system that allows automatic detection and correction of such abnormal excitation rhythms. For the heart, its realization involves the integration of ion channels with newly designed gating properties into cardiomyocytes. This allows cardiac tissue to i) discriminate between normal rhythm and arrhythmia based on frequency-dependent gating and ii) generate an ionic current for termination of the detected arrhythmia. We show in silico, that for both human atrial and ventricular arrhythmias, activation of these channels leads to rapid and repeated restoration of normal excitation rhythm. Experimental validation is provided by injecting the designed channel current for arrhythmia termination in human atrial myocytes using dynamic clamp.

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Citations

Jun 27, 2020·Nature Reviews. Cardiology·Irene Fernández-Ruiz
Dec 5, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Tim De Coster
Dec 20, 2020·Nature Reviews. Cardiology·Emilia Entcheva, Matthew W Kay
Nov 25, 2020·Journal of Cardiovascular Pharmacology·Arie O Verkerk, Ronald Wilders

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Methods Mentioned

BETA
genetic modification

Software Mentioned

BioICD
RTXI dynamic clamp
CellML
Linux
Myokit

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