PMID: 9182769May 30, 1997Paper

Self-seeded fibers formed by Sup35, the protein determinant of [PSI+], a heritable prion-like factor of S. cerevisiae

Cell
J R GloverSusan Lindquist

Abstract

The [PSI+] factor of S. cerevisiae represents a new form of inheritance: cytosolic transmission of an altered phenotype is apparently based upon inheritance of an altered protein structure rather than an altered nucleic acid. The molecular basis of its propagation is unknown. We report that purified Sup35 and subdomains that induce [PSI+] elements in vivo form highly ordered fibers in vitro. Fibers bind Congo red and are rich in beta sheet, characteristics of amyloids found in certain human diseases, including the prion diseases. Some fibers have distinct structures and these, once initiated, are self-perpetuating. Preformed fibers greatly accelerate fiber formation by unpolymerized protein. These data support a "protein-only" seeded polymerization model for the inheritance of [PSI+].

References

Jun 15, 1991·European Journal of Biochemistry·S A DidichenkoV N Smirnov
Aug 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·W E KlunkD J Abraham
Jul 1, 1988·Molecular and Cellular Biology·D J Thiele
Sep 1, 1988·Yeast·B S CoxC S McLaughlin
Jan 1, 1994·Annual Review of Microbiology·S B Prusiner
Jan 1, 1994·Critical Reviews in Clinical Laboratory Sciences·J D Sipe
Dec 1, 1994·Nature·D A ParsellS Lindquist
May 1, 1994·Current Genetics·I Stansfield, M F Tuite
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J H ComeP T Lansbury
Feb 1, 1996·Current Opinion in Structural Biology·J W Kelly
Jun 1, 1996·Bioorganic & Medicinal Chemistry·C L Nesloney, J W Kelly
May 16, 1997·Cell·A L Horwich, J S Weissman
Feb 1, 1997·Chemistry & Biology·J D HarperP T Lansbury
Jan 1, 1995·Chemistry & Biology·P T Lansbury, B Caughey
Feb 1, 1997·Trends in Cell Biology·B Caughey, B Chesebro

❮ Previous
Next ❯

Citations

Apr 7, 2007·Current Genetics·Yakov A VitrenkoSusan W Liebman
May 12, 2004·Biochimica Et Biophysica Acta·Vladimir N Uversky, Anthony L Fink
May 4, 2005·Journal of Structural Biology·Ulrich BaxaAlasdair C Steven
Feb 6, 2004·Trends in Biotechnology·Daizo HamadaKouhei Tsumoto
Dec 10, 2002·Mechanisms of Ageing and Development·Yanming Xing, Keiichi Higuchi
Aug 15, 2001·Research in Microbiology·G Sapriel
Feb 17, 2000·Trends in Cell Biology·T R Serio, S L Lindquist
Dec 12, 2001·Trends in Biochemical Sciences·R B WicknerE Ross
Sep 2, 1999·Trends in Biochemical Sciences·C M Dobson
Apr 5, 2002·Microbes and Infection·Luc Bousset, Ronald Melki
Mar 6, 1999·Current Opinion in Microbiology·J Foster, N Hunter
Feb 27, 2001·Mutation Research·Y O Chernoff
Feb 8, 2002·Developmental Cell·Lev Z Osherovich, Jonathan S Weissman
Jul 3, 2009·Journal of the American Chemical Society·W Seth ChildersDavid G Lynn
Jun 10, 2005·Nature·Rajaraman Krishnan, Susan L Lindquist
Dec 31, 2005·Nature Cell Biology·Eric D RossReed B Wickner
Jan 19, 2010·Nature Chemical Biology·Yumiko OhhashiMotomasa Tanaka
Jun 3, 2005·Nature Reviews. Genetics·James Shorter, Susan Lindquist
Oct 21, 2004·Nature Reviews. Microbiology·Charles Weissmann
Jun 6, 2009·Nature Structural & Molecular Biology·Peter M Tessier, Susan Lindquist
Aug 18, 2009·Nature Structural & Molecular Biology·Jed J W WiltziusDavid Eisenberg
Nov 30, 2010·Nature Structural & Molecular Biology·Jijun DongSusan Lindquist
Mar 23, 2011·Nature Structural & Molecular Biology·Katherine J VergesJonathan S Weissman
Feb 26, 2013·Nature Structural & Molecular Biology·Bindu L RaveendraAnn E McDermott
Oct 11, 2007·Chemical Communications : Chem Comm·Gaolin LiangBing Xu
Feb 20, 1999·The Biochemical Journal·E Fernandez-BellotC Cullin
Dec 12, 2001·European Journal of Biochemistry·G LiT Yu
Feb 26, 2000·Molecular Microbiology·Y O ChernoffS M Belenkiy
Mar 12, 2002·Molecular Microbiology·V Coustou-LinaresS J Saupe
Mar 22, 2002·Cellular Microbiology·Wandy L BeattyDavid G Russell
Aug 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Irina L DerkatchSusan W Liebman
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·M BalbirnieD S Eisenberg
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Marie-Lise MaddeleinSven J Saupe
May 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Huan WangJames Shorter
Dec 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Carmen KrammerIna Vorberg
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ulrich BaxaReed B Wickner
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Bo ChenRobert Tycko
May 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sean J GarrityAnn Hochschild
Apr 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jens TyedmersSusan Lindquist
Jan 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sven U Heinrich, Susan Lindquist
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·H K Edskes, R B Wickner
Aug 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Helen R SaibilAchilleas S Frangakis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.