Self-stabilized silk sericin-based nanoparticles: In vivo biocompatibility and reduced doxorubicin-induced toxicity

Acta Biomaterialia
Doudou HuLiangjun Zhu

Abstract

A variety of colloid stabilizers and cryoprotectants confer improved nanoparticle (NP) colloidal stability and redisperability. However, discounted tumor targetability, delivery efficacy and possible side effects limit the application in vascular delivery of NPs. Here we present water-soluble silk sericin (SS) not only as a material for the preparation of NPs, but also both a dispersion stabilizer and a cryoprotectant. In the absence of any stabilizers, SS-based NPs (SSC@NPs) can resist the adsorption of serum proteins, preventing the formation of particle agglomerates. Following freeze-drying without addition of cryoprotectants, SSC@NPs powder can be easily resuspended into NP dispersion with a nearly monodispersed distribution. Additionally, SSC@NPs do not result in acute toxicity in mice at a dose of 400 mg/kg with a slow injection. Moreover, doxorubicin (DOX)-loaded SSC@NPs (DOX-SSC@NPs) diminish the biodistribution of DOX in the heart, mitigating DOX-induced cardiotoxicity of mice without compromising therapeutic efficacy. Our results suggest that the self-stabilized SSC@NPs could be a secure and effective drug carrier for intravenous administration when deprived of protective agents. During manufacturing process such as f...Continue Reading

Citations

Jun 22, 2019·Expert Opinion on Drug Delivery·Burcin YavuzDavid L Kaplan
Jan 9, 2020·Chemistry : a European Journal·Tingting JiangRui Guo
Dec 3, 2020·Journal of Nanobiotechnology·Anna FlorczakHanna Dams-Kozlowska
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Akram HasanpourAmir Amani
Nov 8, 2020·Materials·Anna FlorczakHanna Dams-Kozlowska
Jun 23, 2020·Annales pharmaceutiques françaises·M ShitoleS Nangare
Jun 13, 2020·International Journal of Pharmaceutics·Evangelos GeorgilisElisabeth Garanger
Dec 10, 2018·ACS Biomaterials Science & Engineering·Annish JainSonia Kapoor
May 13, 2019·ACS Biomaterials Science & Engineering·Shreya MehrotraBiman B Mandal
Jan 9, 2022·Nano Convergence·Yao MiaoChuanbin Mao

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