PMID: 6975784Oct 1, 1981Paper

Self-stimulation of the habenular complex in the rat

Journal of Comparative and Physiological Psychology
R J Sutherland, S Nakajima

Abstract

The rewarding effect of habenular stimulation was studied in 65 rats. The animals learned to bar press for electrical stimulation of the medial or lateral habenular nucleus or the fasciculus retroflexus, but not the surrounding thalamic nuclei. The response rates were moderate and steady and not influenced by food or water deprivation. Habenular self-stimulation was significantly facilitated by placing lesions in the ipsilateral anterior part of the medial forebrain bundle (MFB). Similarly, MFB self-stimulation was enhanced by ipsilateral habenular lesions. Lesions centered in the region of median raphe nucleus suppressed habenular self-stimulation for more than 4 wk. Self-stimulation of median raphe was not affected by habenular lesions. The results show that habenular stimulation can produce a rewarding effect by exciting neurons in the region of the raphe nuclei but apparently without requiring the participation of the well-known MFB reward system.

Citations

Oct 23, 2012·Anatomical Science International·Hidenori Aizawa
Jun 1, 1984·Pharmacology, Biochemistry, and Behavior·S Nakajima
May 1, 1994·Brain Research. Brain Research Reviews·G Ellison
Sep 1, 1985·Behavioural Brain Research·C Bielajew, G Fouriezos
Aug 5, 2003·Pharmacology, Biochemistry, and Behavior·Isabelle M Maisonneuve, Stanley D Glick
Jan 14, 2000·Journal of Neuroscience Methods·A T KonkleC Bielajew
Oct 8, 1999·Behavioural Brain Research·M WaraczynskiA Acheson
Jul 20, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Gaylord Ellison
Aug 23, 2011·Nature Neuroscience·Ethan S Bromberg-Martin, Okihide Hikosaka
May 3, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shahrdad LotfipourJim Boulter
Mar 29, 2011·Annual Review of Neuroscience·Mariella De Biasi, John A Dani
Dec 1, 1991·The International Journal of Neuroscience·R Sandyk
Jun 23, 2009·Neuroscience Letters·Yuhong WangWenhua Zhou
May 16, 2009·Neuroscience Letters·Sarah E McCallum, Stanley D Glick
Oct 22, 2008·European Journal of Pharmacology·Stanley D GlickIsabelle M Maisonneuve
Sep 25, 2007·Behavioural Brain Research·Marie-Claude Morissette, Sandra M Boye
Mar 24, 2007·Neuroscience and Biobehavioral Reviews·Lucas Lecourtier, Peter H Kelly
Jan 6, 2009·The Journal of Comparative Neurology·Uhnoh Kim
Jul 26, 2011·Biochemical Pharmacology·Michael Paolini, Mariella De Biasi
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·K B Franklin
Oct 26, 2005·Neuroscience and Biobehavioral Reviews·Meg A Waraczynski
Dec 16, 1985·Brain Research·P P Rompre, E Miliaressis
Aug 30, 2011·European Journal of Pharmacology·Stanley D GlickIsabelle M Maisonneuve
Mar 10, 2004·Behavioral and Cognitive Neuroscience Reviews·J Shumake, F Gonzalez-Lima

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.