PMID: 9637398Jun 24, 1998Paper

Self-sustained firing of human motor units

Neuroscience Letters
Monica A GorassiniJ F Yang

Abstract

Motoneurons of invertebrates and vertebrates can continue to fire repetitively after being activated by a brief, excitatory synaptic input (self-sustained firing). This firing behavior is due to the activation of intrinsic, voltage-gated currents which produce sustained regenerative depolarizations (plateau potentials) of the cell. Examination of these intrinsic cellular properties has been performed in reduced animal preparations and it is unknown if such self-sustained firing occurs in motoneurons of the intact human. In this paper, we present evidence of this in the human by using a technique of dual motor unit recordings. Subjects were instructed to maintain a constant dorsiflexion effort, and the common synaptic input (e.g. descending drive) onto the tibialis anterior (TA) motoneuron pool was monitored by recording the firing frequency of a low threshold 'control' unit. Once the firing rate of the control unit was constant, vibration of the TA tendon recruited a second 'test' unit which continued to fire after the vibration (i.e. synaptic input) was removed, even though the firing rate of the control unit (and thus, the common drive) remained the same or decreased. Self-sustained firing of motoneurons such as this may redu...Continue Reading

References

Jan 1, 1985·Experimental Brain Research·J Hounsgaard, O Kiehn
Jul 1, 1989·Acta Physiologica Scandinavica·T Eken, O Kiehn
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·D K HartlineK Graubard
Mar 14, 1985·Nature·R Hennig, T Lømo
Jan 1, 1984·Experimental Brain Research·J HounsgaardO Kiehn
Jul 1, 1994·Trends in Neurosciences·C J De Luca, Z Erim
Jan 1, 1994·Experimental Brain Research·R M BrownstoneH Hultborn
Jan 1, 1993·Experimental Brain Research·P RomaiguèreS Pagni

❮ Previous
Next ❯

Citations

May 8, 2002·Muscle & Nerve·T George HornbyDouglas G Stuart
May 29, 2010·Experimental Brain Research·Lydia P Kudina, Regina E Andreeva
May 9, 2012·Journal of Computational Neuroscience·Leonardo Abdala EliasAndré Fabio Kohn
Nov 20, 2003·Trends in Neurosciences·C J HeckmanRobert M Brownstone
Feb 19, 2003·Brain Research. Brain Research Reviews·Jean-François PerrierJørn Hounsgaard
Feb 13, 2001·Brain Research Bulletin·J F Perrier, J Hounsgaard
Jan 23, 1999·Current Opinion in Neurobiology·O Kiehn, T Eken
Aug 6, 2002·Respiratory Physiology & Neurobiology·Duncan L Turner, D Paul Sumners
Dec 21, 2002·The European Journal of Neuroscience·S M KorogodS Tyc-Dumont
Mar 18, 2008·Brain : a Journal of Neurology·Jonathan A NortonMonica A Gorassini
Nov 15, 2011·Brain : a Journal of Neurology·Sylvie RaoulRose Katz
Jul 11, 2007·Exercise and Sport Sciences Reviews·David F Collins
Jan 21, 2010·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Jennifer L Stephenson, Katrina S Maluf
Mar 27, 2010·Journal of Applied Physiology·Mark JesunathadasRoger M Enoka
Jul 10, 2009·Journal of Neurophysiology·Carol J MottramWilliam Z Rymer
Oct 3, 2008·Journal of Neurophysiology·Jacob G McPhersonJulius P A Dewald
Apr 3, 2008·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·C J HeckmanJenna Schuster
Jun 12, 2010·Journal of Neuroengineering and Rehabilitation·Fernando H Magalhães, André F Kohn
Mar 1, 2006·Experimental Brain Research·J M KalmarE Cafarelli
Dec 3, 2008·Experimental Brain Research·Jasper SchuurmansFrans C T van der Helm
Oct 5, 2011·The Journal of Physiology·Marco Alessandro MinettoDario Farina
Jan 21, 2006·The Journal of Physiology·Andrew J FuglevandDouglas A Keen
Nov 29, 2002·The Journal of Physiology·Christine WaltonE Cafarelli
Jan 5, 2002·The Journal of Physiology·D F CollinsS C Gandevia
Jan 5, 2002·The Journal of Physiology·Jørn Hounsgaard
Apr 5, 2011·Journal of Neuroscience Methods·Jennifer L Stephenson, Katrina S Maluf
Jul 31, 2007·Respiratory Physiology & Neurobiology·Jane E Butler
Mar 6, 2007·Neurophysiologie clinique = Clinical neurophysiology·C Rossi-Durand
Aug 2, 2013·Acta Physiologica·C K ThomasI Zijdewind
Aug 16, 2005·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Gary KamenAnita Christie
Dec 3, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jennifer WegrzykJulien Gondin
Nov 19, 2014·Frontiers in Human Neuroscience·Karen SøgaardGisela Sjøgaard
Jun 10, 2009·Journal of Neuroscience Methods·Rune W BergHenrich Cheng
May 27, 2006·Progress in Neurobiology·Robert M Brownstone
Aug 10, 2016·Perceptual and Motor Skills·Barbara M DoucetWaneen Spirduso
Oct 31, 2003·Journal of Neurophysiology·Anna M Taylor, Roger M Enoka
Jul 22, 2016·Journal of Neurophysiology·Joshua C WeavilMarkus Amann
Jun 18, 2003·Muscle & Nerve·Patrick H McCreaAntony J Hodgson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology
Gary KamenAnita Christie
© 2022 Meta ULC. All rights reserved