Selol nanocapsules with a poly(methyl vinyl ether-co-maleic anhydride) shell conjugated to doxorubicin for combinatorial chemotherapy against murine breast adenocarcinoma in vivo

Artificial Cells, Nanomedicine, and Biotechnology
Rayane GanassinLuis Alexandre Muehlmann

Abstract

Nanocapsules containing selol and doxorubicin (NCS-DOX) with an oily core of selol and a shell of poly(methyl vinyl ether-co-maleic anhydride) covalently conjugated to doxorubicin were developed in a previous work. In this study, these nanocapsules showed a similar antitumour effect in comparison to the free doxorubicin (DOX) treatment, but showed no evident DOX-related cardiotoxicity, as evidenced by serum creatine kinase-MB (CK-MB) activity. The histopathological analysis showed that the free DOX treatment induced more intense morphological damage to myocardial tissues in comparison to NCS-DOX treatment. Animals treated with free DOX presented important muscle fibre degradation and animals treated with NCS-DOX, heart tissue did not present signals of muscle fibre degeneration. These results indicate that the cardiotoxicity related to DOX is reduced when this drug is carried by the NCS-DOX. Noteworthy, biodistribution analyses showed that NCS-DOX accumulated more intensely in tumours than the free DOX. Thus, this study reinforces the importance of the development of nanocapsules as drug carriers for the treatment of cancer.

References

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Nov 29, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Rayane GanassinLuis Alexandre Muehlmann

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Citations

Oct 24, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Janaina Moreira CoelhoLuis Alexandre Muehlmann
Sep 15, 2020·Physical Chemistry Chemical Physics : PCCP·Ewa Mosiniewicz-SzablewskaPaulo C Morais
Nov 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Marina Arantes RadicchiJoão Paulo Figueiró Longo
Nov 17, 2020·International Journal of Nanomedicine·Alicja KarabaszKrzysztof Szczepanowicz

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