Semaglutide induces weight loss in subjects with type 2 diabetes regardless of baseline BMI or gastrointestinal adverse events in the SUSTAIN 1 to 5 trials

Diabetes, Obesity & Metabolism
Bo AhrénLawrence A Leiter

Abstract

To assess the effect of baseline body mass index (BMI) and the occurrence of nausea and/or vomiting on weight loss induced by semalgutide, a once-weekly glucagon-like peptide 1 analogue for the treatment of type 2 diabetes. Semaglutide demonstrated superior reductions in HbA1c and superior weight loss (by 2.3-6.3 kg) versus different comparators across the SUSTAIN 1 to 5 trials; the contributing factors to weight loss are not established. Subjects with inadequately controlled type 2 diabetes (drug-naïve or on background treatment) were randomized to subcutaneous semaglutide 0.5 mg (excluding SUSTAIN 3), 1.0 mg (all trials), or comparator (placebo, sitagliptin, exenatide extended release or insulin glargine). Subjects were subdivided by baseline BMI and reporting (yes/no) of any nausea and/or vomiting. Change from baseline in body weight was assessed within each trial and subgroup. A mediation analysis separated weight loss into direct or indirect (mediated by nausea or vomiting) effects. Clinically relevant weight-loss differences were observed across all BMI subgroups, with a trend towards higher absolute weight loss with higher baseline BMI. Overall, 15.2% to 24.0% and 21.5% to 27.2% of subjects experienced nausea or vomiting...Continue Reading

References

Jan 1, 1997·British Medical Bulletin·R T Jung
Mar 21, 1998·The Journal of Clinical Investigation·A FlintJ J Holst
Dec 8, 1998·American Journal of Public Health·T S HanJ C Seidell
Apr 8, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·E NäslundP M Hellström
Jun 19, 2001·American Journal of Physiology. Endocrinology and Metabolism·C M EdwardsS R Bloom
Jun 26, 2013·The New England Journal of Medicine·Rena R WingSusan Z Yanovski
Oct 22, 2013·JAMA : the Journal of the American Medical Association·UNKNOWN World Medical Association
Sep 10, 2014·The Journal of Clinical Investigation·Anna SecherLotte Bjerre Knudsen
Feb 14, 2015·Therapeutic Advances in Endocrinology and Metabolism·Jennifer M TrujilloSamuel L Ellis
Oct 30, 2015·Diabetes, Obesity & Metabolism·Sten Madsbad
May 12, 2016·Cell Metabolism·Carlos A CamposRichard D Palmiter
Sep 17, 2016·The New England Journal of Medicine·Steven P MarsoUNKNOWN SUSTAIN-6 Investigators
Jan 11, 2017·Journal of Diabetes·Payal H MaratheKelly L Close
Feb 6, 2018·The Lancet. Diabetes & Endocrinology·Richard E PratleyUNKNOWN SUSTAIN 7 investigators
Apr 25, 2018·The Journal of Clinical Endocrinology and Metabolism·Helena W RodbardPaul Norwood

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Citations

Feb 16, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Georgios A ChristouDimitrios N Kiortsis
Nov 27, 2019·The Journal of Clinical Endocrinology and Metabolism·C DeSouzaV Fonseca
Apr 30, 2019·Frontiers in Endocrinology·Lotte Bjerre Knudsen, Jesper Lau
May 28, 2019·Current Obesity Reports·Eric Nolen-DoerrIvania Rizo
Jul 31, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Sanjay KalraManilka Sumanatilleke
Aug 12, 2020·Nature Reviews. Nephrology·Neil G Docherty, Carel W le Roux
Oct 30, 2020·The Journal of Clinical Endocrinology and Metabolism·Nawfal W IstfanCaroline M Apovian
Jun 20, 2020·Cell Reports·Tito BornerRobert P Doyle
Mar 27, 2021·Nature Metabolism·Mette Q LudwigTune H Pers
Apr 27, 2021·The Journal of Clinical Endocrinology and Metabolism·Christine B San GiovanniAaron S Kelly
Jun 29, 2021·Expert Opinion on Emerging Drugs·Mathies M Jepsen, Mikkel B Christensen
Jul 27, 2021·Frontiers in Endocrinology·Mark M Smits, Daniël H Van Raalte
Aug 8, 2021·British Journal of Pharmacology·Tito BornerBart C De Jonghe
Jun 29, 2021·Diabetes·Matthew R HayesBart C De Jonghe
Sep 29, 2021·JAMA : the Journal of the American Medical Association·Ildiko LingvayThomas A Wadden
Oct 30, 2021·Journal of the American Heart Association·Elia C El HajjSheldon E Litwin
Oct 27, 2021·Endocrine Reviews·Angeliki M AngelidiChristos S Mantzoros

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