Semantic paralexias: a group-case study on the underlying functional mechanisms, incidence and clinical features in a consecutive series of 340 Italian aphasics

Brain and Language
Maddalena CiaghiG Miceli

Abstract

We studied the reading performance of 340 consecutive, Italian-speaking aphasics in order to evaluate the clinical features of deep dyslexia, the functional impairments underlying semantic paralexias, and their neuranatomical correlates. Semantic paralexias were observed in 9/340 subjects (2.4%). Our data and a review of the literature show that most deep dyslexics suffer from superficial and deep vascular damage in the territory of the left middle cerebral artery, and that they are relatively young, well-educated individuals, in the chronic stage of their disease. In these subjects, perisylvian damage might be mainly responsible for damage to sublexical grapheme-phoneme Conversion (GPC) procedures, and extrasylvian damage for lexical-semantic impairment. Semantic paralexias might originate in the right hemisphere, or in left perilesional regions. The functional impairment underlying deep dyslexia was analyzed with specific reference to the summation hypothesis, i.e., to the hypothesis that in reading, GPC procedures interact with lexical-semantic information, thus blocking semantically incorrect responses. On this account, semantic paralexias should only occur when, in the presence of lexical-semantic damage, GPC rules are dis...Continue Reading

Citations

Dec 11, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anna M Woollams
Dec 15, 2015·Neuropsychologia·Irene Ablinger, Ralph Radach

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