Semaphorin 3A attenuates cardiac autonomic disorders and reduces inducible ventricular arrhythmias in rats with experimental myocardial infarction

BMC Cardiovascular Disorders
Hesheng HuSuhua Yan

Abstract

To investigate the effects of semaphorin 3A (sema 3A) on cardiac autonomic regulation and subsequent ventricular arrhythmias (VAs) in post-infarcted hearts. In order to explore the functions of sema 3A in post-infarcted hearts, lentivirus-Sema 3A-shRNA and negative control vectors were delivered to the peri-infarcted myocardium rats respectively. Meanwhile, recombinant sema 3A and control (0.9% NaCl solution) were injected intravenously into infarcted rats to test the therapeutic potential of sema 3A. Results indicated that levels of sema 3A were higher in post-infarcted hearts compared with sham rats. However, sema 3A silencing leaded to sympathetic hyperinnervation, increased myocardial norepinephrine (NE) content and inducible VAs. Conversely, the intravenous administration of sema 3A to infarcted rats reduced sympathetic nerve sprouting, improved cardiac autonomic regulation, and decreased the incidence of inducible VAs. However, both infarct size and cardiac function were similar among infarcted hearts. The upregulation and administration of sema 3A exerted beneficial effects on infarction-induced cardiac autonomic disorders by increasing cardiac electrical stability and reducing VAs. Sema 3A might be a potential therapeut...Continue Reading

References

Feb 10, 2000·Current Opinion in Cardiology·F NaccarellaA Rolli
Apr 14, 2000·Circulation Research·J M CaoP S Chen
Jan 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Wei LiBeth A Habecker
Jan 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiao-Qing TangGeorge M Smith
Jan 27, 2005·QJM : Monthly Journal of the Association of Physicians·M J ReedP S Addison
Jan 10, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Douglas P Zipes, Michael Rubart
Aug 17, 2006·Journal of Cardiovascular Electrophysiology·Lan S ChenPeng-Sheng Chen
Apr 10, 2007·Nature Medicine·Masaki IedaKeiichi Fukuda
May 14, 2008·Progress in Cardiovascular Diseases·Marmar Vaseghi, Kalyanam Shivkumar
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Jan 15, 2009·Current Treatment Options in Cardiovascular Medicine·Vikas Kuriachan, Derek V Exner
Jul 14, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Diana C ParrishBeth A Habecker
Feb 6, 2010·The Journal of Biological Chemistry·Susan X JiangSheng T Hou
Nov 3, 2010·Current Cardiology Reviews·Masaki Ieda, Keiichi Fukuda
Jan 5, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Stefano GovoniEmilio Vanoli
Jan 5, 2011·Journal of Translational Medicine·Mohamed A NouhBonnie F Sloane
Aug 27, 2011·The Tohoku Journal of Experimental Medicine·Hua-zhi WenBo He
Oct 18, 2011·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Bich Lien NguyenLan S Chen
Jan 24, 2012·Circulation Research·Kensuke KimuraKeiichi Fukuda
Apr 24, 2012·Nature·Mikihito HayashiHiroshi Takayanagi
Jul 28, 2012·Expert Opinion on Therapeutic Targets·Yoshio GoshimaFumio Nakamura
Sep 13, 2013·Frontiers in Physiology·Anastasios Lymperopoulos

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Citations

Jul 21, 2016·Cell Adhesion & Migration·Donatella ValdembriGuido Serini
Jan 30, 2021·Basic Research in Cardiology·Marius KellerPeter Rosenberger
Jun 1, 2021·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Sheng-Feng LuMei-Ling Yu
Apr 4, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Johanna LähteenvuoSeppo Ylä-Herttuala

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BETA
protein assay
fluorescence microscopy

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ImageJ
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