Semaphorin 3A: Is a key player in the pathogenesis of asthma

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Ronen CozacovZahava Vadasz

Abstract

Immune semaphorins are key players in regulating immune mediated inflammation. Semaphorin3A (sema3A) a secreted and membrane bound member of this family, is well reported for its properties in maintaining self-tolerance. Semaphorin3A was recognized to be a marker for T-regulatory cells (Tregs), and as such is a useful tool for assessing the status of these cells in preventing immune mediated diseases. This study was designed aiming to evaluate how sema3A is possibly involved in bronchial asthma. Here, we found sema3A serum levels and the expression of sema3A on Tregs significantly lower in patients with moderate to severe asthma when compared to healthy individuals. Co-culture of condition medium with 2mcg/ml of recombinant human sema3A with CD4+ T cells, increased the expression of FoxP3 in Tregs, suggesting sema3A a potent immune-regulator of inflammation including that of asthma. Further in-vivo studies will better establish the beneficial effect of sema3A in regulating inflammation in asthma.

Citations

Jan 1, 2019·International Forum of Allergy & Rhinology·Rong XiangZe-Zhang Tao
Aug 25, 2019·Allergy·Elias Toubi, Zahava Vadasz
Feb 11, 2020·Frontiers in Cellular and Infection Microbiology·Shui-Zhen WuHong-Juan Peng
Mar 27, 2020·Frontiers in Immunology·Vijaya Iragavarapu-CharyuluAlexandra Urdaneta
Apr 27, 2018·Inflammopharmacology·Li-Na LiuHai-Feng Pan
Mar 26, 2021·American Journal of Rhinology & Allergy·Honghui LiuGuolin Tan
Sep 26, 2021·Inflammation·Rimar DoronVadasz Zahava

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