Semaphorin 3B-associated membranous nephropathy is a distinct type of disease predominantly present in pediatric patients.

Kidney International
Sanjeev SethiPierre Ronco

Abstract

Membranous nephropathy results from subepithelial antigen-antibody complex deposition along the glomerular basement membrane. Although PLA2R, THSD7A, and NELL-1 account for a majority (about 80%) of the target antigens, the target antigen in the remaining cases is not known. Using laser microdissection of PLA2R-negative glomeruli of patients with membranous nephropathy followed by mass spectrometry we identified a unique protein, Semaphorin 3B, in three cases. Mass spectrometry failed to detect Semaphorin-3B in 23 PLA2R-associated cases of membranous nephropathy and 88 controls. Semaphorin 3B in all three cases was localized to granular deposits along the glomerular basement membrane by immunohistochemistry. Next, an additional eight cases of Semaphorin 3B-associated membranous nephropathy were identified in three validation cohorts by immunofluorescence microscopy. In four of 11 cases, kidney biopsy also showed tubular basement membrane deposits of IgG on frozen sections. Confocal microscopy showed that both IgG and Semaphorin 3B co-localized to the glomerular basement membrane. Western blot analysis of five available sera showed reactivity to reduced Semaphorin 3B in four of four patients with active disease and no reactivity...Continue Reading

Citations

Jul 20, 2020·Journal of Nephrology·Andrea AngelettiPaolo Cravedi
Jan 23, 2021·Journal of the American Society of Nephrology : JASN·Aishwarya RavindranSanjeev Sethi
Jan 1, 2021·Journal of the American Society of Nephrology : JASN·Sanjeev Sethi
Feb 11, 2021·Journal of Clinical Medicine·Pierre RoncoHanna Debiec
Mar 7, 2021·Mayo Clinic Proceedings·Shane A BobartAn S De Vriese
Mar 18, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lila HawkinsonNicole K Andeen
Mar 24, 2021·Clinical and Experimental Nephrology·Hae Yoon Grace Choung, Bruce Goldman
Jan 23, 2021·Current Opinion in Nephrology and Hypertension·Pierre Ronco, Hanna Debiec
Apr 4, 2021·Journal of Clinical Medicine·Barbara MoszczukKrzysztof Mucha
Apr 4, 2021·Biomolecules·Yan GuDamu Tang
Apr 10, 2021·Journal of the American Society of Nephrology : JASN·Sanjeev SethiPierre Ronco
Apr 10, 2021·Medicina clínica·Jorge Enrique Rojas-Rivera, Alberto Ortiz Arduán
Apr 8, 2021·Cell and Tissue Research·Nicola M TomasElion Hoxha
Apr 9, 2021·Frontiers in Immunology·Vladimir Tesar, Zdenka Hruskova
Apr 15, 2021·The New England Journal of Medicine·Thomas Benzing, David Salant
Apr 30, 2021·KI Reports·Philipp GaucklerUNKNOWN RITERM study group
May 7, 2021·Journal of the American Society of Nephrology : JASN·Laith Farah Al-RabadiLaurence H Beck
Apr 19, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Johannes MünchJan Halbritter
Nov 4, 2020·Molecular Immunology·Linda ReinhardElion Hoxha
Jun 27, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Reza ZonoziJohn L Niles
Jul 3, 2021·Journal of Clinical Medicine·Roxana JurubițăGener Ismail
Jul 11, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Shan-Shan LiYong Dai
Oct 2, 2021·Nature Reviews. Disease Primers·Pierre RoncoJack Wetzels
Dec 17, 2021·Lupus·Valentina PapaAnthony Chang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Seikagaku. The Journal of Japanese Biochemical Society
Masahiko Taniguchi
Current Biology : CB
Rachel E Jackson, Britta J Eickholt
© 2022 Meta ULC. All rights reserved