Semaphorin 4D expression is associated with a poor clinical outcome in cervical cancer patients

Microvascular Research
Huidong LiuFengmin Zhang

Abstract

Lymphangiogenesis is thought to be essential for cancer progression, making it an important target in cancer therapy. Lymphangiogenic factors (VEGF-C and VEGF-D) are upregulated in various tumors/cancers, and play an important role in lymphangiogenesis and lymph node metastasis. Similarly, semaphorin 4D (Sema4D) is a potent inducer of angiogenesis, and its overexpression is associated with tumor progression and poor prognosis in a variety of malignancies. However, little is known regarding the functional relationship between Sema4D and VEGF-C/VEGF-D and in the mediation of lymphangiogenesis and lymph node metastasis and clinical outcome. The current study aimed to evaluate the effect of Sema4D expression on outcome in patients with cervical cancer, and to explore the molecular mechanism of Sema4D in tumor progression. We evaluated Sema4D expression, density of lymphatic vessels, and invasion of lymphatic vessels with immunohistochemical methods in 232 human cervical cancers with long-term follow-up. Sema4D expression was correlated with patho-clinical parameters and patients' outcome. A cervical cancer cell line was used to investigate the contribution of sema4D to tumor progression by studying the role of Sema4D in VEGF-C/-D a...Continue Reading

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Related Concepts

SEMA4D gene
Tumor Cells, Uncertain Whether Benign or Malignant
Biochemical Pathway
Class V Semaphorins
Adenosquamous Carcinoma
Transfection
Leukocyte Differentiation Antigens, Human
Angiogenic Process
Mitogen-Activated Protein Kinases
RNA, Small Interfering

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