Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses.

Proceedings of the National Academy of Sciences of the United States of America
Brian P O'ConnorJenny P-Y Ting

Abstract

The semaphorin and plexin family of ligand and receptor proteins provides important axon guidance cues required for development. Recent studies have expanded the role of semaphorins and plexins in the regulation of cardiac, circulatory and immune system function. Within the immune system, semaphorins and plexins regulate cell-cell interactions through a complex network of receptor and ligand pairs. Immune cells at different stages of development often express multiple semaphorins and plexins, leading to multivariate interactions, involving more than one ligand and receptor within each functional group. Because of this complexity, the significance of semaphorin and plexin regulation on individual immune cell types has yet to be fully appreciated. In this work, we examined the regulation of T cells by semaphorin 6D. Both in vitro and in vivo T cell stimulation enhanced semaphorin 6D expression. However, semaphorin 6D was only expressed by a majority of T cells during the late phases of activation. Consequently, the targeted disruption of semaphorin 6D receptor-ligand interactions inhibited T cell proliferation at late but not early phases of activation. This proliferation defect was associated with reduced linker of activated T c...Continue Reading

References

Apr 1, 1992·The Journal of Experimental Medicine·Y NojimaC Morimoto
Sep 7, 2001·Current Opinion in Cell Biology·B P Liu, S M Strittmatter
Feb 4, 2003·Nature Reviews. Immunology·Hitoshi Kikutani, Atsushi Kumanogoh
Jun 17, 2003·Nature Immunology·Benedict SeddonRose Zamoyska
Aug 12, 2003·Nature Immunology·Athena W WongJenny P-Y Ting
Sep 25, 2003·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Peter O Krutzik, Garry P Nolan
Dec 10, 2003·The Journal of Experimental Medicine·Robyn M KondrackLinda M Bradley
Dec 17, 2003·The Journal of Experimental Medicine·JiChu LiSusan L Swain
Mar 30, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Peter O KrutzikOmar D Perez
Apr 3, 2004·EMBO Reports·Luca Tamagnone, Paolo M Comoglio
Jul 23, 2004·Current Biology : CB·Patricia A ZipfelAnn Marie Pendergast
Nov 16, 2004·Nature Cell Biology·Toshihiko ToyofukuHitoshi Kikutani
Mar 18, 2005·Annual Review of Immunology·Tania H Watts
Mar 26, 2005·Immunological Reviews·Mary E Keir, Arlene H Sharpe
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter O KrutzikGarry P Nolan
Nov 9, 2005·The Journal of Experimental Medicine·Susanna CelliPhilippe Bousso
May 23, 2006·Nature Cell Biology·Noriko TakegaharaHitoshi Kikutani
Jul 11, 2006·Immunological Reviews·Hans Dooms, Abul K Abbas
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·So-Young EunJenny P-Y Ting
Feb 22, 2007·The Journal of Experimental Medicine·Hans DoomsAbul K Abbas
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Zacarias GarciaPhilippe Bousso
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jing Jin GuAnn Marie Pendergast
Dec 19, 2007·Nature Immunology·Kazuhiro SuzukiHitoshi Kikutani
Jan 22, 2008·Nature Immunology·David Tarlinton
Jan 23, 2008·International Immunology·Midori YamamotoHitoshi Kikutani
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi WataraiMasaru Taniguchi
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Douglas V DolfiPeter D Katsikis

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Citations

Dec 11, 2008·Journal of Clinical Immunology·Masayuki MizuiHitoshi Kikutani
Nov 26, 2010·The Journal of Experimental Medicine·Haitao WenJenny P-Y Ting
Feb 12, 2013·Clinical Reviews in Allergy & Immunology·Zahava Vadasz, Elias Toubi
Jan 7, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kimia T MalekiNiklas K Björkström
May 8, 2013·Cellular Immunology·Grace E LinderDevavani Chatterjea
Oct 27, 2012·Seminars in Cell & Developmental Biology·Michael Rehman, Luca Tamagnone
Feb 14, 2012·Trends in Immunology·Hyota Takamatsu, Atsushi Kumanogoh
Feb 15, 2012·Gene Expression Patterns : GEP·A M EbertS McFarlane
Jan 12, 2013·Protein & Cell·Kelly RoneyJenny Ting
Nov 22, 2011·Differentiation; Research in Biological Diversity·Nina PeräläTiina Immonen
May 23, 2013·Experimental Cell Research·Nina Eissler, Charlotte Rolny
May 15, 2015·International Journal of Breast Cancer·Dongquan ChenKai Jiao
Dec 8, 2017·Nature Reviews. Rheumatology·Masayuki Nishide, Atsushi Kumanogoh
Aug 2, 2014·Nature Reviews. Drug Discovery·Thomas Worzfeld, Stefan Offermanns
Apr 6, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eda K HollJenny P-Y Ting
Aug 24, 2018·Molecular Medicine·Svetlana P Chapoval
Mar 27, 2020·Frontiers in Immunology·Vijaya Iragavarapu-CharyuluAlexandra Urdaneta
Apr 10, 2018·The Journal of Clinical Investigation·Antiopi VareliasGeoffrey R Hill
Jan 20, 2019·International Journal of Molecular Sciences·Giulia Franzolin, Luca Tamagnone
Jun 27, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica K FiegeRyan A Langlois
Sep 10, 2020·Cytokine & Growth Factor Reviews·Damon Fard, Luca Tamagnone

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