Semaphorin III can induce death in sensory neurons

Molecular and Cellular Neurosciences
V Gagliardini, C Fankhauser


Semaphorin III has been described to function as a guidance molecule directing growing axons to their target. However, its effect on the neuron cell body has not been characterized. Semaphorin III has a highly dynamic expression pattern, which generally corroborates a chemorepellent guidance function, but also suggests additional functions, different from axon guidance. A number of studies show that some sensory neurons are eliminated, while their axons are still pathfinding. In this study we have investigated whether Semaphorin III also influences the survival of sensory neurons. We here present evidence that Semaphorin III can function in vitro as selective death factor for NGF-dependent sensory neurons. Semaphorin III induces a type of cell death that is characterized by slow onset, cell body shrinking, nuclear condensation, and TUNEL-positive staining of dying neurons. These are all hallmarks of neuronal apoptosis. We also show evidence that neurons can modulate the response to Semaphorin III. The novel function described here may also be relevant in vivo, contributing to active elimination of neurons during development or after injury.


Jan 1, 1991·Neuroscience·M FitzgeraldL I Benowitz
Jan 10, 1996·Developmental Biology·I ShepherdS Chang
Jun 14, 1996·Cell·A Fraser, G Evan
Nov 15, 1996·Science·M Tessier-Lavigne, C S Goodman
Aug 22, 1997·Cell·A L KolodkinD D Ginty
May 15, 1998·Neuron·B Pettmann, C E Henderson
Sep 28, 1998·The European Journal of Neuroscience·I SkalioraA W Püschel
Dec 16, 1998·The Journal of Biological Chemistry·S OkunoH Matsuda
Apr 10, 1999·Nature Neuroscience·H ChenM Tessier-Lavigne
Apr 10, 1999·Nature Neuroscience·T TakahashiS M Strittmatter
Jan 1, 1996·Trends in Cell Biology·A L Kolodkin

❮ Previous
Next ❯


Feb 6, 2010·The Journal of Biological Chemistry·Susan X JiangSheng T Hou
Apr 6, 2006·Genome Biology·Umar Yazdani, Jonathan R Terman
May 1, 2009·Development·Julaine Roffers-Agarwal, Laura S Gammill
Aug 3, 2001·Journal of Neurochemistry·W SchultzeK S Erdmann
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y TomizawaJ D Minna
Jul 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Emely Castro-RiveraJohn D Minna
Dec 1, 2001·Progress in Neurobiology·S D SkaperF S Walsh
Nov 13, 2002·Neurochemistry International·Bor Luen Tang
Sep 26, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Olga KlebanovArieh S Solomon
Mar 28, 2003·Neoplasia : an International Journal for Oncology Research·Patrick NasarreJoëlle Roche
Feb 8, 2008·Trends in Neurosciences·Kenneth D Harris
Dec 29, 2007·Biochemical and Biophysical Research Communications·Sheng T HouAmy Aylsworth
Feb 18, 2005·Journal of Neurochemistry·Gareth WilliamsPatrick Doherty
Feb 3, 2004·The Journal of Comparative Neurology·Thomas E DillonM William Rochlin
May 28, 2009·Journal of Neuroscience Research·Yoshitaka TaniguchiShinobu Inagaki
Nov 19, 2003·Journal of Neurochemistry·M T Moreno-FloresF Wandosell
Apr 20, 2007·Journal of Neurochemistry·Fanny Mann, Geneviève Rougon
Jun 18, 2005·Brain Research. Brain Research Reviews·María J BarallobreEduardo Soriano
May 25, 2005·Neuroscience Letters·Takao YasuharaIsao Date
Jul 7, 2000·Molecular and Cellular Neurosciences·V GagliardiniC Fankhauser
Mar 10, 2001·Neuron·T Takahashi, S M Strittmatter
Jun 12, 2008·International Review of Cell and Molecular Biology·Sheng T HouRobert A Smith
Jul 8, 2016·Asia-Pacific Journal of Clinical Oncology·Dinesh Singh Tekcham, Pramod Kumar Tiwari
Nov 1, 2001·Nature Neuroscience·T W Gould, R W Oppenheim
May 5, 2016·Development·Amanda B WehnerBrian A Pierchala
Jun 15, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·José Carlos RiveraSylvain Chemtob
Feb 25, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nicola J OsborneBritta J Eickholt
May 10, 2005·Journal of Neuroscience Research·H NishimuneC E Henderson
Nov 6, 2004·Reviews in the Neurosciences·Takao YasuharaIsao Date
May 12, 2020·Wiley Interdisciplinary Reviews. Developmental Biology·Amrita PathakBruce D Carter
Apr 27, 2018·Inflammopharmacology·Li-Na LiuHai-Feng Pan
Nov 7, 2017·Gene Expression Patterns : GEP·Sarah E EmersonAlicia M Ebert

❮ Previous
Next ❯

Related Concepts

Related Feeds


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.