PMID: 15329371Aug 27, 2004Paper

Semaphorin profiling of periodontal fibroblasts and osteoblasts

Journal of Dental Research
Thomas E Lallier

Abstract

Cells of the periodontal attachment (cementoblasts, osteoblasts, and periodontal ligament fibroblasts) are descended from a common progenitor (the cranial neural crest). During their differentiation into different cell types, these cells separate from one another to form a laminated structure. Semaphorins (and their neuropilins and plexin receptors) act as cell guidance molecules for other neural crest derivatives. It is predicted that the differential expression of these molecules will correlate with the ability of these cells to segregate. It is demonstrated that human pre-osteoblasts segregate from PDL and gingival fibroblasts in culture. In addition, these cells express different semaphorins and plexins. Semaphorins 3D and 7A were expressed preferentially in dermal fibroblasts, while semaphorin 6B was selectively expressed by pre-osteoblasts. Semaphorins 3B, 4C, 5B, and 6C and plexins B1 and C1 were expressed in reduced levels in pre-osteoblasts. Analysis of the data suggests that differential expression of semaphorins and plexins may be involved in regulating cell-sorting in the formation and regeneration of the periodontal attachment structure. Periodontal Ligament (PDL), Reverse Transcriptase Polymerase Chain-reaction (R...Continue Reading

References

Jul 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M Bronner-Fraser
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·K T HallG J Freeman
Aug 22, 1997·Cell·A L KolodkinD D Ginty
Oct 26, 2001·Mechanisms of Development·Y HerzogG Neufeld
Aug 24, 2002·Scandinavian Journal of Immunology·S HolmesC Lewis

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Citations

Sep 2, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S K BaniwalB Frenkel
Oct 7, 2006·Cell and Tissue Research·Thomas E Lallier, Amber Spencer
Apr 6, 2006·Genome Biology·Umar Yazdani, Jonathan R Terman
Oct 2, 2009·Journal of Periodontology·Amber Y Spencer, Thomas E Lallier
Apr 14, 2011·Journal of Periodontology·Archontia PalaiologouThomas E Lallier
Jan 22, 2013·Seminars in Cell & Developmental Biology·Bart C JongbloetsR Jeroen Pasterkamp
Mar 11, 2016·Journal of Periodontology·Bruna R AmorimFrancisco H Nociti
Sep 15, 2015·Molecular and Cellular Endocrinology·Lieve VerlindenAnnemieke Verstuyf

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