Abstract
Solid tumors not only comprise malignant cells but also other nonmalignant cell types, forming a unique microenvironment that can strongly influence the behavior of tumor cells. Recent advances in the understanding of cancer biology have highlighted the functional role of semaphorins. In fact, semaphorins form a family of molecular signals known to guide and control cell migration during embryo development and in adults. Tumor cells express semaphorins as well as their receptors, plexins and neuropilins. It has been shown that semaphorin signaling can regulate tumor cell behavior. Moreover, semaphorins are important regulators of tumor angiogenesis. Conversely, very little is known about the functional relevance of semaphorin signals for tumor-infiltrating stromal cells, such as leukocytes. In this chapter, we review the current knowledge on the functional role of semaphorins in cancer progression, and we focus on the emerging role of semaphorins in mediating the cross talk between tumor cells and different tumor stromal cells.
Citations
Oct 30, 2012·Nature Structural & Molecular Biology·Bert J C JanssenE Yvonne Jones
Jan 7, 2016·Expert Opinion on Therapeutic Targets·Mingfu WuFei Ye
Jan 28, 2015·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·E Yvonne Jones
Mar 5, 2014·The Journal of Clinical Investigation·Wei ZhengKari Alitalo
Jun 20, 2013·The Journal of International Medical Research·Changqing GeXu Xu
Mar 29, 2013·International Journal of Molecular Sciences·Maria A VanoniDaniela Zucchini
Jan 19, 2019·International Journal of Molecular Sciences·Samuel Garcia
Jun 30, 2012·Cellular and Molecular Life Sciences : CMLS·Prasanta K Hota, Matthias Buck
Nov 12, 2013·Oncogene·G Cagnoni, L Tamagnone
Sep 18, 2013·Cancer Metastasis Reviews·Brian A Baldo, Nghia H Pham
Sep 6, 2012·Oncotarget·Gérald J Prud'homme, Yelena Glinka
May 10, 2018·Scientific Reports·Brian J GrindelMary C Farach-Carson
Mar 5, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Yuan LiuQuan-Zhong Liu
Feb 22, 2018·Oncotarget·Sugandha SaxenaRakesh K Singh
Jan 12, 2013·Protein & Cell·Kelly RoneyJenny Ting
Jul 28, 2019·Nature Communications·Marine LeclercFathia Mami-Chouaib
Feb 13, 2018·World Journal of Gastroenterology : WJG·Han LiYan-Bing Zhou