PMID: 9184799May 1, 1997Paper

Sematilide blocks the inward rectifier potassium channel in isolated guinea pig ventricular myocytes

General Pharmacology
H TakaiR Katori

Abstract

1. In whole-cell patch recording, the relative potency of the blocking action of sematilide on IK1 was found to be constant at each potential level of IK1 activation. Under more acidic condition, the degree of block was decreased. These results strongly suggested that the neutral form of sematilide may penetrate the cardiac cell membrane via hydrophobic pathway. 2. In cell-attached patches, sematilide prolonged the interburst interval and reduced the opening probabilities of the IK1 channel without affecting either the mean open time or the mean closed time within a burst.

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Jan 2, 1990·The American Journal of Cardiology·M J Antonaccio, A Gomoll
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Citations

Feb 13, 2001·European Journal of Pharmacology·A Belus, E White
May 7, 2003·Progress in Biophysics and Molecular Biology·Andre KamkinHolger Scholz
Mar 10, 1999·Progress in Biophysics and Molecular Biology·M J Lab
Mar 10, 1999·Progress in Biophysics and Molecular Biology·P KohlD Noble
Mar 10, 1999·Progress in Biophysics and Molecular Biology·P Taggart, P M Sutton
Aug 2, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·J C Sánchez, R J Wilkins
May 24, 2000·British Journal of Pharmacology·Y H Zhang, J C Hancox
Jan 24, 2014·Journal of Pharmacological Sciences·Katsuyuki KazusaAtsushi Sugiyama
Jul 24, 1998·Journal of Cardiovascular Pharmacology·J W WegenerH Nawrath

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