Semen characteristics and inflammatory mediators in infertile men with different clinical diagnoses

International Journal of Andrology
Elena MorettiGiulia Collodel

Abstract

This study was aimed at investigating whether semen characteristics in different clinical diagnoses of infertility are associated with PMN elastase, IL-6, IL-8, IL-1beta and TNFalpha levels detected in seminal plasma. Sixty-eight patients were divided into groups according to their clinical diagnosis: idiopathic infertility (group I), varicocele with infections (group II), varicocele (group III), infections (group IV), controls (group V). Physical examination and scrotal Eco-color Doppler was used to detect the varicocele. Patients with positive bacteriological semen analysis were considered as having an infection of the male reproductive tract. Samples were examined by light microscopy and transmission electron microscopy (TEM). TEM data were quantified with a mathematical formula furnishing a fertility index and the percentage of sperm apoptosis, immaturity and necrosis. PMN elastase/alpha1-PI complex levels were determined by ELISA and IL-6, IL-8, IL-1beta, TNFalpha by Bio-Plex Cytokine assay. Sperm concentration (I-II: p < 0.005; III-IV: p < 0.0001), motility (I-IV: p < 0.0001) and the fertility index (I: p < 0.005; II-IV: p < 0.0001) were significantly lower in the groups vs. controls, whereas sperm pathologies, except for...Continue Reading

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Oct 6, 2007·Journal of Andrology·Giulia Collodel, Elena Moretti

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Citations

Feb 23, 2013·Der Urologe. Ausg. A·A PilatzT Bschleipfer
Oct 5, 2010·Human Reproduction·Karel SoucekAles Hampl
Jul 14, 2012·Systems Biology in Reproductive Medicine·Steve DorusTimothy L Karr
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May 18, 2016·Reproduction, Fertility, and Development·Nicola A PascarelliGiulia Collodel
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Jul 12, 2018·American Journal of Reproductive Immunology : AJRI·Giuseppe GrandeAlfredo Pontecorvi
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Jul 11, 2020·Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis·Brilliance Onyinyechi Anyanwu, Orish Ebere Orisakwe
Nov 28, 2019·Oxidative Medicine and Cellular Longevity·Elena MorettiDaniela Cerretani
Jun 19, 2013·Allergy & Rhinology·Gabriela Ruth MendelukLuis Alberto Palaoro
Mar 4, 2021·Scientific Reports·Giulia CollodelElena Moretti
Mar 11, 2021·Andrologia·Renata FinelliFrancesco Lombardo
Apr 4, 2021·International Journal of Molecular Sciences·Daniele SantiManuela Simoni

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