Semen Microbiome Biogeography: An Analysis Based on a Chinese Population Study

Frontiers in Microbiology
Zhanshan Ma, Lianwei Li

Abstract

Investigating inter-subject heterogeneity (or spatial distribution) of human semen microbiome diversity is of important significance. Theoretically, the spatial distribution of biodiversity constitutes the core of microbiome biogeography. Practically, the inter-subject heterogeneity is crucial for understanding the normal (healthy) flora of semen microbiotas as well as their possible changes associated with abnormal fertility. In this article, we analyze the scaling (changes) of semen microbiome diversity across individuals with DAR (diversity-area relationship) analysis, a recent extension to classic SAR (species-area relationship) law in biogeography and ecology. Specifically, the unit of "area" is individual subject, and the microbial diversity in seminal fluid of an individual (area) is assessed via metagenomic DNA sequencing technique and measured in the Hill numbers. The DAR models were then fitted to the accrued diversity across different number of individuals (area size). We further tested the difference in DAR parameters among the healthy, subnormal, and abnormal microbiome samples in terms of their fertility status based on a cross-sectional study of a Chinese cohort. Given that no statistically significant difference...Continue Reading

References

Mar 31, 1999·Human Reproduction Update·C KeckM Breckwoldt
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·J B PlotkinP S Ashton
Jan 13, 2006·World Journal of Urology·Ralf HenkelWolfgang Weidner
Jan 15, 2008·Fertility and Sterility·Ann A KiesslingRobert C Eyre
Mar 14, 2008·Andrologia·F R Ochsendorf
Dec 18, 2008·Journal of Assisted Reproduction and Genetics·Elena MorettiGiulia Collodel
Jan 14, 2009·Ecology·Even Tjørve, Kathleen M Calf Tjørve
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Nov 26, 2010·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Maria Antonia De FrancescoNino Manca
Oct 28, 2011·The American Naturalist·Arnošt L SizlingDavid Storch
Oct 26, 2012·Ecology·Anne ChaoT C Hsieh
Sep 3, 2013·Fertility and Sterility·Dongsheng HouChen Xu
Sep 26, 2014·Nature·Matthew R HelmusJonathan B Losos

❮ Previous
Next ❯

Citations

Nov 17, 2019·Nature Reviews. Urology·Signe AltmäeReet Mändar
May 18, 2021·Computational and Structural Biotechnology Journal·Wendy Li, Zhanshan Sam Ma
Nov 18, 2021·Critical Reviews in Microbiology·Richard CariñoMasahiro Umezaki

❮ Previous
Next ❯

Methods Mentioned

BETA
RIP

Software Mentioned

DAR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.