Semen phthalate metabolites, semen quality parameters and serum reproductive hormones: A cross-sectional study in China

Environmental Pollution
Yi-Xin WangWen-Qing Lu

Abstract

Exposure to phthalates has been found to have adverse effects on male reproductive function in animals. However, the findings from human studies are inconsistent. Here we examined the associations of phthalate exposure with semen quality and reproductive hormones in a Chinese population using phthalate metabolite concentrations measured in semen as biomarkers. Semen (n = 687) and blood samples (n = 342) were collected from the male partners of sub-fertile couples who presented to the Reproductive Center of Tongji Hospital in Wuhan, China. Semen quality parameters and serum reproductive hormone levels were determined. Semen concentrations of 8 phthalate metabolites were assessed using high-performance liquid chromatography and tandem mass spectrometry. Associations of the semen phthalate metabolites with semen quality parameters and serum reproductive hormones were assessed using confounder-adjusted linear and logistic regression models. Semen phthalate metabolites were significantly associated with decreases in semen volume [mono-n-butyl phthalate (MBP), mono-(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)], sperm curvilinear velocity [monobenzyl phthal...Continue Reading

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Citations

Sep 28, 2016·Environment International·Ioanna KatsikantamiApostolos K Rizos
Jan 9, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nelli Giribabu, Pamanji Sreenivasula Reddy
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Sep 24, 2020·International Journal of Environmental Research and Public Health·Henrieta HlisníkováAlexander Sirotkin
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Apr 21, 2021·Current Medical Science·Hua-Hua JiangYu-Feng Li
May 10, 2021·The Science of the Total Environment·Wei-Hsiang ChangHsiu-Ling Chen

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