Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic.

Reproductive Toxicology
John D MeekerRuss Hauser

Abstract

Bisphenol A (BPA) impairs spermatogenesis in animals, but human studies are lacking. We measured urinary BPA concentrations, semen quality, and sperm DNA damage (comet assay) in 190 men recruited through an infertility clinic. BPA was detected in 89% of samples, with a median (interquartile range [IQR]) concentration of 1.3 (0.8-2.5) ng/mL. Urinary BPA concentration was associated with slightly elevated, though not statistically significant, odds for below reference sperm concentration, motility, and morphology. When modeled as continuous dependent variables, an IQR increase in urinary BPA concentration was associated with declines in sperm concentration, motility, and morphology of 23% (95%CI -40%, -0.3%), 7.5% (-17%, +1.5%), and 13% (-26%, -0.1%), respectively, along with a 10% (0.03%, 19%) increase in sperm DNA damage measured as the percentage of DNA in comet tail. In conclusion, urinary BPA may be associated with declined semen quality and increased sperm DNA damage, but confirmatory studies are needed.

Citations

May 3, 2014·Environmental Health Perspectives·Tina Harmer LassenAnna-Maria Andersson
Jan 8, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Hanne FrederiksenAnna-Maria Andersson
Mar 20, 2014·Annual Review of Public Health·Laura S RozekGilbert S Omenn
Apr 23, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ravindranath Reddy GilibiliStelvio M Bandiera
Jun 22, 2014·Dental Materials : Official Publication of the Academy of Dental Materials·Xiaoxu LiangJingwei He
May 23, 2014·Occupational and Environmental Medicine·Nicola CherryUNKNOWN participating centres of CHAPS-UK
May 16, 2014·Environmental Monitoring and Assessment·Hassan R Dhaini, Rana M Nassif
May 9, 2014·Cardiovascular Toxicology·Nikki Gillum Posnack
Oct 23, 2014·Environmental Health : a Global Access Science Source·Jillian Ashley-MartinWilliam D Fraser
Sep 30, 2010·Environmental Health Perspectives·John D MeekerRuss Hauser
Nov 11, 2010·Environmental Health Perspectives·Erin M Rees ClaytonAllison E Aiello
Jun 19, 2013·Reproductive Toxicology·Dinesh Tiwari, Geeta Vanage
Oct 12, 2012·Human Reproduction·M C Sánchez-PozoUNKNOWN Special Interest Group in Andrology of the European Society of Human Reproduction and Embriology
May 4, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Silvio De FloraSaverio Bettuzzi
Jul 23, 2013·Reproductive Biology and Endocrinology : RB&E·Rakesh SharmaAshok Agarwal
Mar 23, 2013·Environmental Science and Pollution Research International·Catarina MansilhaIsabel M P L V O Ferreira
Oct 9, 2015·International Journal of Environmental Research and Public Health·Cinzia La RoccaAlberto Mantovani
Jul 24, 2014·International Journal of Environmental Research and Public Health·Guergana MilevaCatherine Bielajew
Jan 24, 2012·Drug and Chemical Toxicology·Małgorzata M Dobrzyńska, Joanna Radzikowska
Jan 31, 2016·Reviews in Endocrine & Metabolic Disorders·Polyxeni Nicolopoulou-StamatiAnnie J Sasco
Jun 19, 2013·The Journal of Evidence-based Dental Practice·Julia M Akeroyd, Nancy N Maserejian
May 18, 2013·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Martin HulakPavla Linhartova
Mar 27, 2013·International Journal of Hygiene and Environmental Health·Hanne FrederiksenLisbeth E Knudsen
Mar 16, 2013·International Journal of Hygiene and Environmental Health·Hanne FrederiksenAnna-Maria Andersson
Jun 29, 2012·Neurotoxicology·Camille A MartinaShanna H Swan
Jan 17, 2012·Mutation Research·Dinesh TiwariGeeta Vanage
Nov 1, 2011·Ecotoxicology and Environmental Safety·Azadeh HatefOtomar Linhart
Aug 23, 2011·Neurotoxicology and Teratology·Kimberly YoltonJane Khoury
Sep 6, 2011·Toxicology Letters·Alexandros G AsimakopoulosMichael A Koupparis
Dec 15, 2015·Fertility and Sterility·Lidia Mínguez-AlarcónUNKNOWN EARTH Study Team
Jan 12, 2013·Andrology·Jaime MendiolaAlberto M Torres-Cantero
Jun 21, 2012·Environmental Toxicology and Chemistry·Azadeh HatefOtomar Linhart

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved