Semen Quality as a Predictor of Subsequent Morbidity: A Danish Cohort Study of 4,712 Men With Long-Term Follow-up

American Journal of Epidemiology
Tabassam LatifRune Lindahl-Jacobsen

Abstract

Semen quality has been suggested to be a biological marker of long-term morbidity and mortality; however, few studies have been conducted on this subject. We identified 5,370 men seen for infertility at Frederiksberg Hospital, Denmark, during 1977-2010, and 4,712 of these men were followed in the Danish National Patient Registry until first hospitalization, death, or the end of the study. We classified patients according to hospitalizations and the presence of cardiovascular disease, diabetes, testicular cancer, or prostate cancer. We found a clear association between sperm concentration below 15 million/mL and all-cause hospitalizations (hazard ratio = 1.5, 95% confidence interval: 1.4, 1.6) and cardiovascular disease (hazard ratio = 1.4, 95% confidence interval: 1.2, 1.6), compared with men with a concentration above 40 million/mL. The probabilities for hospitalizations were also higher with a low total sperm count and low motility. Men with a sperm concentration of 195-200 million/mL were, on average, hospitalized for the first time 7 years later than were men with a sperm concentration of 0-5 million/mL. Semen quality was associated with long-term morbidity, and a significantly higher risk of hospitalization was found, in p...Continue Reading

References

Sep 12, 1992·BMJ : British Medical Journal·E CarlsenN E Skakkebaek
Feb 2, 1995·The New England Journal of Medicine·J AugerP Jouannet
Jun 12, 1998·JAMA : the Journal of the American Medical Association·P M LantzJ Chen
Feb 26, 1999·BMJ : British Medical Journal·H Møller, N E Skakkebaek
Sep 29, 2000·BMJ : British Medical Journal·R JacobsenH Moller
Jun 4, 2002·Human Reproduction·Tina Kold JensenNiels E Skakkebaek
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·A-M AnderssonN E Skakkebaek
Jul 24, 2004·International Journal of Andrology·Niels E Skakkebaek
Oct 16, 2004·Fertility and Sterility·Tina Kold JensenNiels E Skakkebaek
Feb 25, 2005·International Journal of Cancer. Journal International Du Cancer·Aleksander GiwercmanOlof Akre
Jul 12, 2005·Toxicology and Applied Pharmacology·H E VirtanenJ Toppari
Feb 10, 2006·International Journal of Andrology·Niels JørgensenNiels E Skakkebaek
Sep 13, 2006·Human Reproduction·C H Ramlau-HansenJ P Bonde
Jun 26, 2007·Fertility and Sterility·Tina K JensenNiels Erik Skakkebaek
Dec 11, 2007·Fertility and Sterility·Anette S AggerholmJens Peter Bonde
Jan 8, 2008·Fertility and Sterility·Ahmad O HammoudA Wayne Meikle
Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Karen P Phillips, Warren G Foster
Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Karen P Phillips, Nongnuj Tanphaichitr
Nov 8, 2008·Nature Medicine·Martin M Matzuk, Dolores J Lamb
Feb 25, 2009·Archives of Internal Medicine·Thomas J WalshPaul J Turek
Mar 20, 2009·European Urology·Andrea SaloniaFrancesco Montorsi
Jul 29, 2009·American Journal of Epidemiology·Tina Kold JensenErik Bostofte
Nov 26, 2009·Human Reproduction Update·Trevor G CooperKirsten M Vogelsong
Mar 24, 2010·Cancer·Thomas J WalshMary S Croughan
Aug 6, 2011·The Journal of Clinical Endocrinology and Metabolism·Andre B AraujoGary A Wittert
Mar 1, 2012·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Brandon ChockArthur Swislocki
Jun 25, 2013·Fertility and Sterility·Michael L EisenbergLarry I Lipshultz
Nov 19, 2013·Journal of the American Heart Association·Peyman Mesbah OskuiRobert A Kloner
Apr 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Karen R KilcoyneRichard M Sharpe
May 20, 2014·Human Reproduction·Michael L EisenbergLarry I Lipshultz
Jun 27, 2014·European Journal of Epidemiology·Morten SchmidtHenrik Toft Sørensen
Dec 3, 2014·The Journal of Urology·Michael L EisenbergLaurence C Baker
Dec 17, 2014·Fertility and Sterility·Michael L EisenbergMark R Cullen
May 27, 2015·Fertility and Sterility·Eugenio VentimigliaAndrea Salonia
Nov 26, 2015·Clinical Epidemiology·Morten SchmidtHenrik Toft Sørensen
Dec 18, 2015·Fertility and Sterility·Michael L EisenbergLaurence C Baker

❮ Previous
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Citations

Mar 16, 2018·Expert Review of Molecular Diagnostics·Csilla KrauszAntoni Riera-Escamilla
Oct 6, 2017·Human Reproduction Update·Hagai LevineShanna H Swan
Oct 27, 2017·European Journal of Endocrinology·Stine A HolmboeAnna-Maria Andersson
Jan 15, 2019·Epidemiology·G David BattyMartin J Shipley
Nov 7, 2019·Andrology·UNKNOWN Cairo Consensus Workshop Group
May 7, 2020·Antioxidants & Redox Signaling·Gabriel Gojon, Guillermo A Morales
Sep 21, 2020·Aging Cell·Sandra LaurentinoJörg Gromoll
Oct 12, 2018·Human Reproduction Update·Alison E HipwellUNKNOWN program collaborators for Environmental influences on Child Health Outcomes
Jul 16, 2020·Investigative and Clinical Urology·Francesco Del GiudiceMichael L Eisenberg
Aug 20, 2018·BMJ Open·Ane Berger BungumSandra Søgaard Tøttenborg
Jun 16, 2018·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Csilla KrauszJordi Surrallés
Nov 15, 2019·Human Reproduction·Clara Helene GlazerJens Peter Bonde
Nov 5, 2020·Human Reproduction Update·Linda G KahnUNKNOWN program collaborators for Environmental Influences on Child Health Outcomes Program
Oct 6, 2020·Urology·Francesco Del GiudiceMichael L Eisenberg
Sep 2, 2020·Environment International·Ramy Abou GhaydaUNKNOWN Russian Children's Study
Jan 28, 2021·Human Reproduction·Guido PenningsWillem Ombelet
Dec 29, 2020·Deutsches Ärzteblatt International·Sabine Kliesch
Aug 21, 2019·European Urology Focus·Alberto FerlinCarlo Foresta
Jan 9, 2018·Fertility and Sterility·Liina NagirnajaDonald F Conrad
Apr 4, 2021·Journal of Clinical Medicine·Rossella CannarellaSandro La Vignera
Apr 6, 2021·Urology·Francesco Del GiudiceMichael L Eisenberg
May 20, 2021·Human Reproduction·L J AhrenfeldtR Lindahl-Jacobsen
Jun 29, 2021·Frontiers in Genetics·Semyon KolmykovAlexander Osadchuk
Sep 12, 2021·The Journal of Clinical Endocrinology and Metabolism·Rune HoltMartin Blomberg Jensen

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