Semen quality associated with subsequent hospitalizations - Can the effect be explained by socio-economic status and lifestyle factors?

Andrology
Tabassam LatifT K Jensen

Abstract

Semen quality is suggested to be a universal biomarker for future health. Previous studies have mostly been registry based excluding the possibility to address the importance of lifestyle, fertility status, health and socio-economic status. We aimed to investigate whether the association between semen quality and subsequent risk of hospitalization could be explained by differences in occupation, education, fertility, cryptorchidism, BMI or smoking; 1423 men with first semen sample at Fertility Clinic, Frederiksberg Hospital, Denmark, from 1977 to 2010 responded to a questionnaire in 2012 about current health, lifestyle, educational level and occupation. They were followed in the Danish National Patient Registry to first-time hospitalizations using ICD-8 and ICD-10 classification. Data were analysed by Cox proportional hazard regression models to adjust for the possible confounding factors. We found a significant higher risk of being hospitalized with decreasing sperm concentrations (0-15 mill/mL: HR1.78, 95% CI:1.51-2.09; 16-50 mill/mL: HR 1.37 95% CI: 1.17-1.60; 51-100 mill/mL: HR1.25 95% CI: 1.07-1.45). Same significant association of being hospitalized with decreasing total sperm counts was seen. The dose-response increase i...Continue Reading

References

Sep 12, 1992·BMJ : British Medical Journal·E CarlsenN E Skakkebaek
Jun 12, 1998·JAMA : the Journal of the American Medical Association·P M LantzJ Chen
Feb 26, 1999·BMJ : British Medical Journal·H Møller, N E Skakkebaek
May 9, 2000·The American Journal of Clinical Nutrition·K M Godfrey, D J Barker
Jun 4, 2002·Human Reproduction·Tina Kold JensenNiels E Skakkebaek
Jul 24, 2004·International Journal of Andrology·Niels E Skakkebaek
Oct 16, 2004·Fertility and Sterility·Tina Kold JensenNiels E Skakkebaek
Jul 12, 2005·Toxicology and Applied Pharmacology·H E VirtanenJ Toppari
Sep 13, 2006·Human Reproduction·C H Ramlau-HansenJ P Bonde
Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Karen P Phillips, Warren G Foster
Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Karen P Phillips, Nongnuj Tanphaichitr
Nov 8, 2008·Nature Medicine·Martin M Matzuk, Dolores J Lamb
Jul 29, 2009·American Journal of Epidemiology·Tina Kold JensenErik Bostofte
Sep 23, 2009·Nature Reviews. Cardiology·Alexander M ClarkAndy Wielgosz
Nov 26, 2009·Human Reproduction Update·Trevor G CooperKirsten M Vogelsong
Aug 6, 2011·The Journal of Clinical Endocrinology and Metabolism·Andre B AraujoGary A Wittert
Dec 18, 2012·Human Reproduction Update·N SermondadeS Czernichow
Oct 1, 2013·Systems Biology in Reproductive Medicine·Joanna JurewiczWojciech Hanke
Nov 19, 2013·Journal of the American Heart Association·Peyman Mesbah OskuiRobert A Kloner
Jun 27, 2014·European Journal of Epidemiology·Morten SchmidtHenrik Toft Sørensen
Nov 26, 2015·Clinical Epidemiology·Morten SchmidtHenrik Toft Sørensen
Dec 18, 2015·Fertility and Sterility·Michael L EisenbergLaurence C Baker
May 13, 2017·American Journal of Epidemiology·Tabassam LatifRune Lindahl-Jacobsen
Oct 6, 2017·Human Reproduction Update·Hagai LevineShanna H Swan

❮ Previous
Next ❯

Citations

Jan 15, 2019·Epidemiology·G David BattyMartin J Shipley
Aug 30, 2019·Expert Review of Endocrinology & Metabolism·Giulia RastrelliGiovanni Corona
Nov 7, 2019·Andrology·UNKNOWN Cairo Consensus Workshop Group
Jul 16, 2020·Investigative and Clinical Urology·Francesco Del GiudiceMichael L Eisenberg
Mar 7, 2021·International Journal of Molecular Sciences·Francesco LottiMario Maggi
Sep 15, 2020·Molecular and Cellular Endocrinology·Guillaume Martinez, Cécile Garcia
May 20, 2021·Human Reproduction·L J AhrenfeldtR Lindahl-Jacobsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.