Semi-automated detection of the foveal avascular zone in fluorescein angiograms in diabetes mellitus

Clinical & Experimental Ophthalmology
J ConrathB Ridings

Abstract

The foveal avascular zone (FAZ) is known to enlarge in diabetic retinopathy. In a preliminary study, the authors applied a region growing algorithm to fluorescein angiograms to detect the FAZ in a semi-automated fashion. The FAZ in 44 fluorescein angiograms of 44 eyes of 41 patients with diabetic retinopathy underwent manual outlining, then analysis with the region growing function of the ENVI image analysis software. The same algorithm was applied after median filtering of the images. Correlation coefficient was 0.98 between the first two authors, 0.89 between the first author and semi-automated detection before median filtering and 0.91 after median filtering. Average surface areas however, were smaller with semi-automated detection (1951 pixels before and 2226 pixels after median filtering) than with manual detection (3032 pixels). Semi-automated detection of the FAZ is possible, but refinements need to be made in angiogram quality and/or image pretreatment to improve results.

References

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Citations

Jan 29, 2011·Medical & Biological Engineering & Computing·M H Ahmad FadzilHanung Adi Nugroho
Jun 25, 2010·Computers in Biology and Medicine·M H Ahmad FadzilHanung Adi Nugroho
Jan 14, 2020·The American Journal of Clinical Hypnosis·José Antonio Molina-PeralM Elena Mendoza
Oct 27, 2006·Current Opinion in Ophthalmology

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