Semi-interpenetrating network hyaluronic acid microgel delivery systems in micro-flow

Journal of Colloid and Interface Science
Qiqing ChenWenhui Song

Abstract

Macroscopic hydrogels are commonly used as injectable scaffolds or fillers, however they may easily obstruct blood vessels, which poses risks and limits their clinical use. In the present study, three types of hyaluronic acid (HA)-based hydrogel micro-particles with non-covalent, covalent semi-interpenetrating and conventional 3D molecular networks, have been designed, fabricated and characterized. The micro-particles are spherical, biconcave or irregular in shape and their diameter ranged between 2.5 and 3.5 µm; their suspensions exhibit a tuneable viscosity, shear-thinning behaviour, dynamic stability and dispersity in microfluidic flow as a result of their specific particulate nature, providing thus a well-controlled injectable platform. Hydrogel particle suspensions also demonstrate an enhanced safety profile, in terms of the dispersity, cell safety, and hemocompatibility. In addition, Rhodamine 6G has successfully been loaded and released from the particles as a model for drug delivery. Functionalisation of hydrogel microparticles using synthetic polymers has been proven to be a cost-effective way to achieve desirable rheological properties and flow dynamic stability with improved physicochemical properties and biocompatib...Continue Reading

Citations

Jan 19, 2019·Current Pharmaceutical Design·Chahinez HouacineKamalinder K Singh
Aug 27, 2019·Frontiers in Cardiovascular Medicine·Malebogo NgoepeThomas Franz
Oct 11, 2019·ACS Biomaterials Science & Engineering·Kayla J Wolf, Sanjay Kumar

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